Details
| Original language | English |
|---|---|
| Pages (from-to) | 135-140 |
| Number of pages | 6 |
| Journal | Bulgarian Chemical Communications |
| Volume | 46 |
| Issue number | 1 |
| Publication status | Published - 2014 |
Abstract
The present paper reports the synthesis and characterization of novel dicoumarinamines (7) as potential bioisostere compounds of dicoumarols (4). 3,3'-Methylenebis(4-amino-2H-chromen-2-one) (7a) was obtained in high yield in a reaction of 4-aminocoumarine (5) with aqueous formaldehyde. Best results in reactions of 5 with aldehydes 6 (b-h) were obtained when reactions were performed in acidified ethanol as a solvent. The structure and relative stability of the possible rotamers were studied by DFT methods at B3LYP/6-31+G** level with regard to their potential biological activity.
Keywords
- Aminocoumarins, Anticoagulant, Bioisostere, Dft, Dicoumarols
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
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In: Bulgarian Chemical Communications, Vol. 46, No. 1, 2014, p. 135-140.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Synthesis and structure of some novel dicoumarinamines
AU - Mikhova, B.
AU - Janevska, V.
AU - Stamboliyska, B.
AU - Draeger, G.
AU - Popovski, E.
N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - The present paper reports the synthesis and characterization of novel dicoumarinamines (7) as potential bioisostere compounds of dicoumarols (4). 3,3'-Methylenebis(4-amino-2H-chromen-2-one) (7a) was obtained in high yield in a reaction of 4-aminocoumarine (5) with aqueous formaldehyde. Best results in reactions of 5 with aldehydes 6 (b-h) were obtained when reactions were performed in acidified ethanol as a solvent. The structure and relative stability of the possible rotamers were studied by DFT methods at B3LYP/6-31+G** level with regard to their potential biological activity.
AB - The present paper reports the synthesis and characterization of novel dicoumarinamines (7) as potential bioisostere compounds of dicoumarols (4). 3,3'-Methylenebis(4-amino-2H-chromen-2-one) (7a) was obtained in high yield in a reaction of 4-aminocoumarine (5) with aqueous formaldehyde. Best results in reactions of 5 with aldehydes 6 (b-h) were obtained when reactions were performed in acidified ethanol as a solvent. The structure and relative stability of the possible rotamers were studied by DFT methods at B3LYP/6-31+G** level with regard to their potential biological activity.
KW - Aminocoumarins
KW - Anticoagulant
KW - Bioisostere
KW - Dft
KW - Dicoumarols
UR - http://www.scopus.com/inward/record.url?scp=84897142781&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84897142781
VL - 46
SP - 135
EP - 140
JO - Bulgarian Chemical Communications
JF - Bulgarian Chemical Communications
SN - 0861-9808
IS - 1
ER -