Details
| Original language | English |
|---|---|
| Pages (from-to) | 253-257 |
| Number of pages | 5 |
| Journal | CHEMBIOCHEM |
| Volume | 3 |
| Issue number | 2-3 |
| Publication status | Published - 1 Mar 2002 |
| Externally published | Yes |
Abstract
β-oxoacyl thiolesters of N-acetylcysteamine (SNACs, see structure) were synthesised and shown to be substrates for the self-acylation reaction of the Type II actinorhodin polyketide synthase holo acyl carrier protein (ACP). The preparation of ACPs bearing analogues of polyketide biosynthesis intermediates is described.
Keywords
- Acyl carrier protein, Biosynthesis, Intermediates, Polyketides
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Medicine
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Chemistry(all)
- Organic Chemistry
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In: CHEMBIOCHEM, Vol. 3, No. 2-3, 01.03.2002, p. 253-257.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Synthesis and characterisation of acyl carrier protein bound polyketide analogues
AU - Arthur, Christopher
AU - Cox, Russell J.
AU - Crosby, John
AU - Rahman, Mujiber M.
AU - Simpson, Thomas J.
AU - Soulas, Florilene
AU - Spogli, Roberto
AU - Szafranska, Anna E.
AU - Westcott, James
AU - Winfield, Christopher J.
PY - 2002/3/1
Y1 - 2002/3/1
N2 - β-oxoacyl thiolesters of N-acetylcysteamine (SNACs, see structure) were synthesised and shown to be substrates for the self-acylation reaction of the Type II actinorhodin polyketide synthase holo acyl carrier protein (ACP). The preparation of ACPs bearing analogues of polyketide biosynthesis intermediates is described.
AB - β-oxoacyl thiolesters of N-acetylcysteamine (SNACs, see structure) were synthesised and shown to be substrates for the self-acylation reaction of the Type II actinorhodin polyketide synthase holo acyl carrier protein (ACP). The preparation of ACPs bearing analogues of polyketide biosynthesis intermediates is described.
KW - Acyl carrier protein
KW - Biosynthesis
KW - Intermediates
KW - Polyketides
UR - http://www.scopus.com/inward/record.url?scp=0036523469&partnerID=8YFLogxK
U2 - 10.1002/1439-7633(20020301)3:2/3<253::AID-CBIC253>3.0.CO;2-7
DO - 10.1002/1439-7633(20020301)3:2/3<253::AID-CBIC253>3.0.CO;2-7
M3 - Article
C2 - 11921408
AN - SCOPUS:0036523469
VL - 3
SP - 253
EP - 257
JO - CHEMBIOCHEM
JF - CHEMBIOCHEM
SN - 1439-4227
IS - 2-3
ER -