Details
| Original language | English |
|---|---|
| Pages (from-to) | 13549-13552 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 51 |
| Publication status | Published - 16 Dec 2013 |
Abstract
Synthesis can provide molecules such as paleo-soraphens A and B (see scheme) that are genetically encoded but not obtained from the natural source. Although it is unclear whether this is part of an evolutionary process or the consequence of the chemical synthesis, the biological evaluation of these genetically encoded natural products can shed light on how natural products are structurally optimized with respect to their biological profile.
Keywords
- acetyl-CoA carboxylase, antitumor agents, evolution, paleo-soraphens, polyketides
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: Angewandte Chemie - International Edition, Vol. 52, No. 51, 16.12.2013, p. 13549-13552.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Synthesis and biological evaluation of paleo-soraphens
AU - Lu, Hai Hua
AU - Raja, Aruna
AU - Franke, Raimo
AU - Landsberg, Dirk
AU - Sasse, Florenz
AU - Kalesse, Markus
PY - 2013/12/16
Y1 - 2013/12/16
N2 - Synthesis can provide molecules such as paleo-soraphens A and B (see scheme) that are genetically encoded but not obtained from the natural source. Although it is unclear whether this is part of an evolutionary process or the consequence of the chemical synthesis, the biological evaluation of these genetically encoded natural products can shed light on how natural products are structurally optimized with respect to their biological profile.
AB - Synthesis can provide molecules such as paleo-soraphens A and B (see scheme) that are genetically encoded but not obtained from the natural source. Although it is unclear whether this is part of an evolutionary process or the consequence of the chemical synthesis, the biological evaluation of these genetically encoded natural products can shed light on how natural products are structurally optimized with respect to their biological profile.
KW - acetyl-CoA carboxylase
KW - antitumor agents
KW - evolution
KW - paleo-soraphens
KW - polyketides
UR - http://www.scopus.com/inward/record.url?scp=84890453926&partnerID=8YFLogxK
U2 - 10.1002/anie.201305331
DO - 10.1002/anie.201305331
M3 - Article
C2 - 24346938
AN - SCOPUS:84890453926
VL - 52
SP - 13549
EP - 13552
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 51
ER -