Synthesis and biological evaluation of paleo-soraphens

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Hai Hua Lu
  • Aruna Raja
  • Raimo Franke
  • Dirk Landsberg
  • Florenz Sasse
  • Markus Kalesse

External Research Organisations

  • Helmholtz Centre for Infection Research (HZI)
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Details

Original languageEnglish
Pages (from-to)13549-13552
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number51
Publication statusPublished - 16 Dec 2013

Abstract

Synthesis can provide molecules such as paleo-soraphens A and B (see scheme) that are genetically encoded but not obtained from the natural source. Although it is unclear whether this is part of an evolutionary process or the consequence of the chemical synthesis, the biological evaluation of these genetically encoded natural products can shed light on how natural products are structurally optimized with respect to their biological profile.

Keywords

    acetyl-CoA carboxylase, antitumor agents, evolution, paleo-soraphens, polyketides

ASJC Scopus subject areas

Cite this

Synthesis and biological evaluation of paleo-soraphens. / Lu, Hai Hua; Raja, Aruna; Franke, Raimo et al.
In: Angewandte Chemie - International Edition, Vol. 52, No. 51, 16.12.2013, p. 13549-13552.

Research output: Contribution to journalArticleResearchpeer review

Lu HH, Raja A, Franke R, Landsberg D, Sasse F, Kalesse M. Synthesis and biological evaluation of paleo-soraphens. Angewandte Chemie - International Edition. 2013 Dec 16;52(51):13549-13552. doi: 10.1002/anie.201305331
Lu, Hai Hua ; Raja, Aruna ; Franke, Raimo et al. / Synthesis and biological evaluation of paleo-soraphens. In: Angewandte Chemie - International Edition. 2013 ; Vol. 52, No. 51. pp. 13549-13552.
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