Synthesis and Biological Evaluation of Epidithio-, Epitetrathio-, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8 '-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents

K. C. Nicolaou; Min Lu; Sotirios Totokotsopoulos; Philipp Heretsch; Denis Giguere; Ya-Ping Sun; David Sarlah; Thu H. Nguyen; Ian C. Wolf; Donald F. Smee; Craig W. Day; Selina Bopp; Elizabeth A. Winzeler

doi:10.1021/ja308429f

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Original language	English
Pages (from-to)	17320-17332
Journal	Journal of the American Chemical Society
Volume	134
Issue number	41
Publication status	Published - 17 Oct 2012

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Synthesis and Biological Evaluation of Epidithio-, Epitetrathio-, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8 '-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents. / Nicolaou, K. C.; Lu, Min; Totokotsopoulos, Sotirios et al.
In: Journal of the American Chemical Society, Vol. 134, No. 41, 17.10.2012, p. 17320-17332.

Research output: Contribution to journal › Article › Research › peer review

Nicolaou, KC, Lu, M, Totokotsopoulos, S, Heretsch, P, Giguere, D, Sun, Y-P, Sarlah, D, Nguyen, TH, Wolf, IC, Smee, DF, Day, CW, Bopp, S & Winzeler, EA 2012, 'Synthesis and Biological Evaluation of Epidithio-, Epitetrathio-, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8 '-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents', Journal of the American Chemical Society, vol. 134, no. 41, pp. 17320-17332. https://doi.org/10.1021/ja308429f

Nicolaou, K. C., Lu, M., Totokotsopoulos, S., Heretsch, P., Giguere, D., Sun, Y.-P., Sarlah, D., Nguyen, T. H., Wolf, I. C., Smee, D. F., Day, C. W., Bopp, S., & Winzeler, E. A. (2012). Synthesis and Biological Evaluation of Epidithio-, Epitetrathio-, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8 '-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents. Journal of the American Chemical Society, 134(41), 17320-17332. https://doi.org/10.1021/ja308429f

Nicolaou KC, Lu M, Totokotsopoulos S, Heretsch P, Giguere D, Sun YP et al. Synthesis and Biological Evaluation of Epidithio-, Epitetrathio-, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8 '-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents. Journal of the American Chemical Society. 2012 Oct 17;134(41):17320-17332. doi: 10.1021/ja308429f

Nicolaou, K. C. ; Lu, Min ; Totokotsopoulos, Sotirios et al. / Synthesis and Biological Evaluation of Epidithio-, Epitetrathio-, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8 '-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents. In: Journal of the American Chemical Society. 2012 ; Vol. 134, No. 41. pp. 17320-17332.

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title = "Synthesis and Biological Evaluation of Epidithio-, Epitetrathio-, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8 '-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents",

author = "Nicolaou, {K. C.} and Min Lu and Sotirios Totokotsopoulos and Philipp Heretsch and Denis Giguere and Ya-Ping Sun and David Sarlah and Nguyen, {Thu H.} and Wolf, {Ian C.} and Smee, {Donald F.} and Day, {Craig W.} and Selina Bopp and Winzeler, {Elizabeth A.}",

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T1 - Synthesis and Biological Evaluation of Epidithio-, Epitetrathio-, and bis-(Methylthio)diketopiperazines: Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8 '-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E, and Haematocin and Discovery of New Antiviral and Antimalarial Agents

AU - Nicolaou, K. C.

AU - Lu, Min

AU - Totokotsopoulos, Sotirios

AU - Heretsch, Philipp

AU - Giguere, Denis

AU - Sun, Ya-Ping

AU - Sarlah, David

AU - Nguyen, Thu H.

AU - Wolf, Ian C.

AU - Smee, Donald F.

AU - Day, Craig W.

AU - Bopp, Selina

AU - Winzeler, Elizabeth A.

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DO - 10.1021/ja308429f

M3 - Article

VL - 134

SP - 17320

EP - 17332

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 41

ER -

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