Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)

Om P. Mishra; Nicholas Simmons; Sonia Tyagi; Ralph Pietrofesa; Vladimir V. Shuvaev; Roman A. Valiulin; Philipp Heretsch; K. C. Nicolaou; Melpo Christofidou-Solomidou

doi:10.1016/j.bmcl.2013.07.062

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Original language	English
Pages (from-to)	5325-5328
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	19
Publication status	Published - 1 Oct 2013

Keywords

Antioxidant, SDG, Free radical scavenger, Flaxseed lignans, ROS

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Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). / Mishra, Om P.; Simmons, Nicholas; Tyagi, Sonia et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 23, No. 19, 01.10.2013, p. 5325-5328.

Research output: Contribution to journal › Article › Research › peer review

Mishra, OP, Simmons, N, Tyagi, S, Pietrofesa, R, Shuvaev, VV, Valiulin, RA, Heretsch, P, Nicolaou, KC & Christofidou-Solomidou, M 2013, 'Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)', Bioorganic and Medicinal Chemistry Letters, vol. 23, no. 19, pp. 5325-5328. https://doi.org/10.1016/j.bmcl.2013.07.062

Mishra, O. P., Simmons, N., Tyagi, S., Pietrofesa, R., Shuvaev, V. V., Valiulin, R. A., Heretsch, P., Nicolaou, K. C., & Christofidou-Solomidou, M. (2013). Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorganic and Medicinal Chemistry Letters, 23(19), 5325-5328. https://doi.org/10.1016/j.bmcl.2013.07.062

Mishra OP, Simmons N, Tyagi S, Pietrofesa R, Shuvaev VV, Valiulin RA et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorganic and Medicinal Chemistry Letters. 2013 Oct 1;23(19):5325-5328. doi: 10.1016/j.bmcl.2013.07.062

Mishra, Om P. ; Simmons, Nicholas ; Tyagi, Sonia et al. / Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). In: Bioorganic and Medicinal Chemistry Letters. 2013 ; Vol. 23, No. 19. pp. 5325-5328.

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title = "Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)",

keywords = "Antioxidant, SDG, Free radical scavenger, Flaxseed lignans, ROS",

author = "Mishra, {Om P.} and Nicholas Simmons and Sonia Tyagi and Ralph Pietrofesa and Shuvaev, {Vladimir V.} and Valiulin, {Roman A.} and Philipp Heretsch and Nicolaou, {K. C.} and Melpo Christofidou-Solomidou",

note = "Funding information: We thank Drs. D.H. Huang, L. Pasternack, and R. Chadha for NMR spectroscopic and X-ray crystallographic assistance. This work was funded in part by The Skaggs Institute for Research, the National Science Foundation (graduate fellowship to N.S.), Merck (postdoctoral fellowship to R.A.V.), the Deutsche Akademie der Naturforscher Leopoldina (postdoctoral fellowship to P.H.), NIH-R01 CA133470 (M.C.S.), NIH-RC1AI081251 (M.C.S.), the University of Pennsylvania Research Foundation (M.C.S.) and by pilot project support from 1P30 ES013508-02 awarded to M.C.S. (its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, NIH).",

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TY - JOUR

T1 - Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)

AU - Mishra, Om P.

AU - Simmons, Nicholas

AU - Tyagi, Sonia

AU - Pietrofesa, Ralph

AU - Shuvaev, Vladimir V.

AU - Valiulin, Roman A.

AU - Heretsch, Philipp

AU - Nicolaou, K. C.

AU - Christofidou-Solomidou, Melpo

N1 - Funding information: We thank Drs. D.H. Huang, L. Pasternack, and R. Chadha for NMR spectroscopic and X-ray crystallographic assistance. This work was funded in part by The Skaggs Institute for Research, the National Science Foundation (graduate fellowship to N.S.), Merck (postdoctoral fellowship to R.A.V.), the Deutsche Akademie der Naturforscher Leopoldina (postdoctoral fellowship to P.H.), NIH-R01 CA133470 (M.C.S.), NIH-RC1AI081251 (M.C.S.), the University of Pennsylvania Research Foundation (M.C.S.) and by pilot project support from 1P30 ES013508-02 awarded to M.C.S. (its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, NIH).

PY - 2013/10/1

Y1 - 2013/10/1

KW - Antioxidant

KW - SDG

KW - Free radical scavenger

KW - Flaxseed lignans

KW - ROS

U2 - 10.1016/j.bmcl.2013.07.062

DO - 10.1016/j.bmcl.2013.07.062

M3 - Article

VL - 23

SP - 5325

EP - 5328

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 19

ER -

Research@Leibniz University

Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)

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