Details
| Original language | English |
|---|---|
| Pages (from-to) | 4665-4668 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 40 |
| Issue number | 25 |
| Publication status | Published - 25 Feb 1999 |
| Externally published | Yes |
Abstract
The preparation of novel head-to-head spacer-linked bisdaunosamine homodimers 8, 15 and 18 is described. The synthesis is achieved by double glycosylation of monosilylated 1,4-butanediol 9 using silyl glycoside 5 as glycosyl donor. Alternatively, olefin metathesis of allyl glycosides α-11 and particularly of α-12 constitutes a second route toward 8 and its unsaturated derivative 15 while non symmetrical dimer 18 has been obtained by cross metathesis of allyl glycosides 11 and 12.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Tetrahedron Letters, Vol. 40, No. 25, 25.02.1999, p. 4665-4668.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Syntheses of spacer-linked neodisaccharides derived from L-Daunosamine
AU - Kirschning, Andreas
AU - Chen, Guang Wu
N1 - Funding information: Acknowledgement: We thank the Deutsche Forschungsgemeinschaft (SFB 416) as well as the Fonds der Chemischen Industrie for financial support.
PY - 1999/2/25
Y1 - 1999/2/25
N2 - The preparation of novel head-to-head spacer-linked bisdaunosamine homodimers 8, 15 and 18 is described. The synthesis is achieved by double glycosylation of monosilylated 1,4-butanediol 9 using silyl glycoside 5 as glycosyl donor. Alternatively, olefin metathesis of allyl glycosides α-11 and particularly of α-12 constitutes a second route toward 8 and its unsaturated derivative 15 while non symmetrical dimer 18 has been obtained by cross metathesis of allyl glycosides 11 and 12.
AB - The preparation of novel head-to-head spacer-linked bisdaunosamine homodimers 8, 15 and 18 is described. The synthesis is achieved by double glycosylation of monosilylated 1,4-butanediol 9 using silyl glycoside 5 as glycosyl donor. Alternatively, olefin metathesis of allyl glycosides α-11 and particularly of α-12 constitutes a second route toward 8 and its unsaturated derivative 15 while non symmetrical dimer 18 has been obtained by cross metathesis of allyl glycosides 11 and 12.
UR - http://www.scopus.com/inward/record.url?scp=0033580860&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(99)00862-X
DO - 10.1016/S0040-4039(99)00862-X
M3 - Article
AN - SCOPUS:0033580860
VL - 40
SP - 4665
EP - 4668
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 25
ER -