Details
| Original language | English |
|---|---|
| Pages (from-to) | 4539-4542 |
| Number of pages | 4 |
| Journal | Chemical communications |
| Volume | 56 |
| Issue number | 33 |
| Early online date | 17 Mar 2020 |
| Publication status | Published - 28 Apr 2020 |
| Externally published | Yes |
Abstract
Mixed 2′-F-riboguanosine and 2′-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Materials Science(all)
- Ceramics and Composites
- Chemistry(all)
- General Chemistry
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Metals and Alloys
- Materials Science(all)
- Materials Chemistry
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In: Chemical communications, Vol. 56, No. 33, 28.04.2020, p. 4539-4542.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions
AU - Haase, Linn
AU - Weisz, Klaus
N1 - Funding Information: We thank the Deutsche Forschungsgemeinschaft for financial support (grant no. WE 1933/15-1).
PY - 2020/4/28
Y1 - 2020/4/28
N2 - Mixed 2′-F-riboguanosine and 2′-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.
AB - Mixed 2′-F-riboguanosine and 2′-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.
UR - http://www.scopus.com/inward/record.url?scp=85084028153&partnerID=8YFLogxK
U2 - 10.1039/d0cc01285h
DO - 10.1039/d0cc01285h
M3 - Article
VL - 56
SP - 4539
EP - 4542
JO - Chemical communications
JF - Chemical communications
SN - 0022-4936
IS - 33
ER -