Details
| Original language | English |
|---|---|
| Article number | e0231421 |
| Journal | PLOS ONE |
| Volume | 15 |
| Issue number | 4 |
| Publication status | Published - Apr 2020 |
| Externally published | Yes |
Abstract
Polymers are commonly used in medical device manufacturing, e.g. for drug delivery systems, bone substitutes and stent coatings. Especially hydrogels exhibit very promising properties in this field. Hence, the development of new hydrogel systems for customized application is of great interest, especially regarding the swelling behavior and mechanical properties as well as the biocompatibility. The aim of this work was the preparation and investigation of various polyelectrolyte and poly-ionic liquid based hydrogels accessible by radical polymerization. The obtained polymers were covalently crosslinked with N,N’-methylenebisacrylamide (MBAA) or different lengths of poly(ethyleneglycol)diacrylate (PEGDA). The effect of different crosslinker-to-monomer ratios has been examined. In addition to the compression curves and the maximum degree of swelling, the biocompatibility with L929 mouse fibroblasts of these materials was determined in direct cell seeding experiments and the outcome for the different hydrogels was compared.
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In: PLOS ONE, Vol. 15, No. 4, e0231421, 04.2020.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Swelling characteristics and biocompatibility of ionic liquid based hydrogels for biomedical applications
AU - Claus, Johanna
AU - Brietzke, Andreas
AU - Lehnert, Celina
AU - Oschatz, Stefan
AU - Grabow, Niels
AU - Kragl, Udo
N1 - Publisher Copyright: © 2020 Claus et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2020/4
Y1 - 2020/4
N2 - Polymers are commonly used in medical device manufacturing, e.g. for drug delivery systems, bone substitutes and stent coatings. Especially hydrogels exhibit very promising properties in this field. Hence, the development of new hydrogel systems for customized application is of great interest, especially regarding the swelling behavior and mechanical properties as well as the biocompatibility. The aim of this work was the preparation and investigation of various polyelectrolyte and poly-ionic liquid based hydrogels accessible by radical polymerization. The obtained polymers were covalently crosslinked with N,N’-methylenebisacrylamide (MBAA) or different lengths of poly(ethyleneglycol)diacrylate (PEGDA). The effect of different crosslinker-to-monomer ratios has been examined. In addition to the compression curves and the maximum degree of swelling, the biocompatibility with L929 mouse fibroblasts of these materials was determined in direct cell seeding experiments and the outcome for the different hydrogels was compared.
AB - Polymers are commonly used in medical device manufacturing, e.g. for drug delivery systems, bone substitutes and stent coatings. Especially hydrogels exhibit very promising properties in this field. Hence, the development of new hydrogel systems for customized application is of great interest, especially regarding the swelling behavior and mechanical properties as well as the biocompatibility. The aim of this work was the preparation and investigation of various polyelectrolyte and poly-ionic liquid based hydrogels accessible by radical polymerization. The obtained polymers were covalently crosslinked with N,N’-methylenebisacrylamide (MBAA) or different lengths of poly(ethyleneglycol)diacrylate (PEGDA). The effect of different crosslinker-to-monomer ratios has been examined. In addition to the compression curves and the maximum degree of swelling, the biocompatibility with L929 mouse fibroblasts of these materials was determined in direct cell seeding experiments and the outcome for the different hydrogels was compared.
UR - http://www.scopus.com/inward/record.url?scp=85083513072&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0231421
DO - 10.1371/journal.pone.0231421
M3 - Article
C2 - 32310981
AN - SCOPUS:85083513072
VL - 15
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 4
M1 - e0231421
ER -