Details
| Original language | English |
|---|---|
| Article number | 296 |
| Number of pages | 15 |
| Journal | Gels |
| Volume | 8 |
| Issue number | 5 |
| Publication status | Published - 12 May 2022 |
Abstract
Hydrogels have become an increasingly interesting topic in numerous fields of applica-tion. In addition to their use as immobilization matrixes in (bio)catalysis, they are widely used in the medical sector, e.g., in drug delivery systems, contact lenses, biosensors, electrodes, and tissue engineering. Cartilage tissue engineering hydrogels from natural origins, such as colla-gen, hyaluronic acid, and gelatin, are widely known for their good biocompatibility. However, they often lack stability, reproducibility, and mechanical strength. Synthetic hydrogels, on the other hand, can have the advantage of tunable swelling and mechanical properties, as well as good reproducibility and lower costs. In this study, we investigated the swelling and mechanical properties of synthetic polyelectrolyte hydrogels. The resulting characteristics such as swelling degree, stiffness, stress, as well as stress-relaxation and cyclic loading behavior, were compared to a commercially available biomaterial, the ChondroFiller® liquid, which is already used to treat articular cartilage lesions. Worth mentioning are the observed good reproducibility and high mechanical strength of the synthetic hydrogels. We managed to synthesize hydrogels with a wide range of compressive moduli from 2.5 ± 0.1 to 1708.7 ± 67.7 kPa, which addresses the span of human articular cartilage.
Keywords
- cartilage lesion, compression, cyclic loading, hydrogel, mechanical characterization, polyelectrolyte, stress-relaxation, substitute material, swelling, synthetic polymer
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Materials Science(all)
- Biomaterials
- Chemistry(all)
- Organic Chemistry
- Materials Science(all)
- Polymers and Plastics
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In: Gels, Vol. 8, No. 5, 296, 12.05.2022.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Swelling and Mechanical Characterization of Polyelectrolyte Hydrogels as Potential Synthetic Cartilage Substitute Materials
AU - Romischke, Johanna
AU - Scherkus, Anton
AU - Saemann, Michael
AU - Krueger, Simone
AU - Bader, Rainer
AU - Kragl, Udo
AU - Meyer, Johanna
N1 - Funding Information: Funding: The publication of this article was funded by the Open Access Fund of Leibniz Universität Hannover. This research was funded by the Bundesministerium für Bildung und Forschung (BMBF, Federal Ministry of Education and Research) within “Zwanzig20”, grant number: 03ZZ0933L (J.R., A.S., U.K.) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), grant number: SFB 1270/1—299150580 (M.S., S.K., R.B.).
PY - 2022/5/12
Y1 - 2022/5/12
N2 - Hydrogels have become an increasingly interesting topic in numerous fields of applica-tion. In addition to their use as immobilization matrixes in (bio)catalysis, they are widely used in the medical sector, e.g., in drug delivery systems, contact lenses, biosensors, electrodes, and tissue engineering. Cartilage tissue engineering hydrogels from natural origins, such as colla-gen, hyaluronic acid, and gelatin, are widely known for their good biocompatibility. However, they often lack stability, reproducibility, and mechanical strength. Synthetic hydrogels, on the other hand, can have the advantage of tunable swelling and mechanical properties, as well as good reproducibility and lower costs. In this study, we investigated the swelling and mechanical properties of synthetic polyelectrolyte hydrogels. The resulting characteristics such as swelling degree, stiffness, stress, as well as stress-relaxation and cyclic loading behavior, were compared to a commercially available biomaterial, the ChondroFiller® liquid, which is already used to treat articular cartilage lesions. Worth mentioning are the observed good reproducibility and high mechanical strength of the synthetic hydrogels. We managed to synthesize hydrogels with a wide range of compressive moduli from 2.5 ± 0.1 to 1708.7 ± 67.7 kPa, which addresses the span of human articular cartilage.
AB - Hydrogels have become an increasingly interesting topic in numerous fields of applica-tion. In addition to their use as immobilization matrixes in (bio)catalysis, they are widely used in the medical sector, e.g., in drug delivery systems, contact lenses, biosensors, electrodes, and tissue engineering. Cartilage tissue engineering hydrogels from natural origins, such as colla-gen, hyaluronic acid, and gelatin, are widely known for their good biocompatibility. However, they often lack stability, reproducibility, and mechanical strength. Synthetic hydrogels, on the other hand, can have the advantage of tunable swelling and mechanical properties, as well as good reproducibility and lower costs. In this study, we investigated the swelling and mechanical properties of synthetic polyelectrolyte hydrogels. The resulting characteristics such as swelling degree, stiffness, stress, as well as stress-relaxation and cyclic loading behavior, were compared to a commercially available biomaterial, the ChondroFiller® liquid, which is already used to treat articular cartilage lesions. Worth mentioning are the observed good reproducibility and high mechanical strength of the synthetic hydrogels. We managed to synthesize hydrogels with a wide range of compressive moduli from 2.5 ± 0.1 to 1708.7 ± 67.7 kPa, which addresses the span of human articular cartilage.
KW - cartilage lesion
KW - compression
KW - cyclic loading
KW - hydrogel
KW - mechanical characterization
KW - polyelectrolyte
KW - stress-relaxation
KW - substitute material
KW - swelling
KW - synthetic polymer
UR - http://www.scopus.com/inward/record.url?scp=85130560546&partnerID=8YFLogxK
U2 - 10.3390/gels8050296
DO - 10.3390/gels8050296
M3 - Article
AN - SCOPUS:85130560546
VL - 8
JO - Gels
JF - Gels
IS - 5
M1 - 296
ER -