Details
| Original language | English |
|---|---|
| Article number | 2202290 |
| Number of pages | 9 |
| Journal | Advanced healthcare materials |
| Volume | 12 |
| Issue number | 10 |
| Early online date | 23 Dec 2022 |
| Publication status | Published - 17 Apr 2023 |
Abstract
Oxidative stress is a cause for numerous diseases and aging processes. Thus, researchers are keen to tune the level of intracellular stress and to learn from that. An unusual approach is presented here. The methodology involves multifunctional surfactants. Although their molecular design is nonbiological—a fullerenol head group attached covalently to pi-conjugated dyes—the surfactants possess superior biocompatibility. Using an intrinsic fluorescence signal as a probe, it is shown that the amphiphiles become incorporated into the Caco-2 cells. There, they are able to exhibit additional functions. The compound reduces cellular stress in dark reaction pathways. The antagonistic property is activated under irradiation, the photocatalytic production of reactive oxygen species (ROS), resulting in cell damage. The feature is activated even by near-infrared light (NIR-light) via a two-photon process. The properties as molecular semiconductors lead to a trojan horse situation and allows the programming of the spatial distribution of cytotoxicity.
Keywords
- biocompatible amphiphiles, reactive oxygen species, self-assembly, semiconductor surfactants
ASJC Scopus subject areas
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
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In: Advanced healthcare materials, Vol. 12, No. 10, 2202290, 17.04.2023.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Surfactant Semiconductors as Trojan Horses in Cell-Membranes for On-Demand and Spatial Regulation of Oxidative Stress
AU - Jaschke, Marian
AU - Plenge, Masina
AU - Kunkel, Marius
AU - Lehrich, Tina
AU - Schmidt, Julia
AU - Stöckemann, Kilian
AU - Heinemann, Dag
AU - Siroky, Stephan
AU - Ngezahayo, Anaclet
AU - Polarz, Sebastian
N1 - Funding Information: M.J. and M.P. contributed equally to this work. The authors thank Helma Feierabend for technical support. Open access funding enabled and organized by Projekt DEAL.
PY - 2023/4/17
Y1 - 2023/4/17
N2 - Oxidative stress is a cause for numerous diseases and aging processes. Thus, researchers are keen to tune the level of intracellular stress and to learn from that. An unusual approach is presented here. The methodology involves multifunctional surfactants. Although their molecular design is nonbiological—a fullerenol head group attached covalently to pi-conjugated dyes—the surfactants possess superior biocompatibility. Using an intrinsic fluorescence signal as a probe, it is shown that the amphiphiles become incorporated into the Caco-2 cells. There, they are able to exhibit additional functions. The compound reduces cellular stress in dark reaction pathways. The antagonistic property is activated under irradiation, the photocatalytic production of reactive oxygen species (ROS), resulting in cell damage. The feature is activated even by near-infrared light (NIR-light) via a two-photon process. The properties as molecular semiconductors lead to a trojan horse situation and allows the programming of the spatial distribution of cytotoxicity.
AB - Oxidative stress is a cause for numerous diseases and aging processes. Thus, researchers are keen to tune the level of intracellular stress and to learn from that. An unusual approach is presented here. The methodology involves multifunctional surfactants. Although their molecular design is nonbiological—a fullerenol head group attached covalently to pi-conjugated dyes—the surfactants possess superior biocompatibility. Using an intrinsic fluorescence signal as a probe, it is shown that the amphiphiles become incorporated into the Caco-2 cells. There, they are able to exhibit additional functions. The compound reduces cellular stress in dark reaction pathways. The antagonistic property is activated under irradiation, the photocatalytic production of reactive oxygen species (ROS), resulting in cell damage. The feature is activated even by near-infrared light (NIR-light) via a two-photon process. The properties as molecular semiconductors lead to a trojan horse situation and allows the programming of the spatial distribution of cytotoxicity.
KW - biocompatible amphiphiles
KW - reactive oxygen species
KW - self-assembly
KW - semiconductor surfactants
UR - http://www.scopus.com/inward/record.url?scp=85146362142&partnerID=8YFLogxK
U2 - 10.1002/adhm.202202290
DO - 10.1002/adhm.202202290
M3 - Article
C2 - 36564363
AN - SCOPUS:85146362142
VL - 12
JO - Advanced healthcare materials
JF - Advanced healthcare materials
SN - 2192-2640
IS - 10
M1 - 2202290
ER -