Details
| Original language | English |
|---|---|
| Pages (from-to) | 6378-6386 |
| Number of pages | 9 |
| Journal | ACS Applied Nano Materials |
| Volume | 1 |
| Issue number | 11 |
| Early online date | 30 Oct 2018 |
| Publication status | Published - 26 Nov 2018 |
| Externally published | Yes |
Abstract
The combination of chemo- and biocatalysts offers a powerful platform to address synthetic challenges in chemistry, particularly in synthetic cascades. However, transferring both catalysts into organic solvents remains technically difficult because of the enzyme inactivation and catalyst precipitation. Herein, we designed a facile approach using functionalized mesoporous silica nanoparticles (MSN) to transfer chemo- and biocatalysts into a variety of organic solvents. As a proof-of-concept, two distinct catalysts, palladium nanoparticles (Pd NPs) and Candida antarctica lipase B (CalB), were stepwise loaded into separate locations of the mesoporous structure, which not only provided catalysts with heterogeneous supports for the recycling but also avoided their mutual inactivation. Moreover, mesoporous particles were hydrophobized by surface alkylation, resulting in a tailor-made particle hydrophobicity, which allowed bifunctional catalysts to be dispersed in eight organic solvents. Eventually, these attractive material properties provided the MSN-based bifunctional catalysts with remarkable catalytic performance for cascade reaction synthesizing benzyl hexanoate in toluene. With a broader perspective, the success of this study opens new avenues in the field of multifunctional catalysts where a plethora of other chemo- and biocatalysts can be incorporated into surface-functionalized materials ranging from soft matters to porous networks for synthetic purposes in organic solvents.
Keywords
- cascade reaction, lipase CalB, mesoporous silica nanoparticles (MSN), multifunctional biocatalyst, palladium nanoparticles
ASJC Scopus subject areas
- Materials Science(all)
- General Materials Science
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In: ACS Applied Nano Materials, Vol. 1, No. 11, 26.11.2018, p. 6378-6386.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Surface-Functionalized Mesoporous Nanoparticles as Heterogeneous Supports to Transfer Bifunctional Catalysts into Organic Solvents for Tandem Catalysis
AU - Zhang, Ningning
AU - Hübner, René
AU - Wang, Yangxin
AU - Zhang, En
AU - Zhou, Yujian
AU - Dong, Shengyi
AU - Wu, Changzhu
N1 - Publisher Copyright: © 2018 American Chemical Society.
PY - 2018/11/26
Y1 - 2018/11/26
N2 - The combination of chemo- and biocatalysts offers a powerful platform to address synthetic challenges in chemistry, particularly in synthetic cascades. However, transferring both catalysts into organic solvents remains technically difficult because of the enzyme inactivation and catalyst precipitation. Herein, we designed a facile approach using functionalized mesoporous silica nanoparticles (MSN) to transfer chemo- and biocatalysts into a variety of organic solvents. As a proof-of-concept, two distinct catalysts, palladium nanoparticles (Pd NPs) and Candida antarctica lipase B (CalB), were stepwise loaded into separate locations of the mesoporous structure, which not only provided catalysts with heterogeneous supports for the recycling but also avoided their mutual inactivation. Moreover, mesoporous particles were hydrophobized by surface alkylation, resulting in a tailor-made particle hydrophobicity, which allowed bifunctional catalysts to be dispersed in eight organic solvents. Eventually, these attractive material properties provided the MSN-based bifunctional catalysts with remarkable catalytic performance for cascade reaction synthesizing benzyl hexanoate in toluene. With a broader perspective, the success of this study opens new avenues in the field of multifunctional catalysts where a plethora of other chemo- and biocatalysts can be incorporated into surface-functionalized materials ranging from soft matters to porous networks for synthetic purposes in organic solvents.
AB - The combination of chemo- and biocatalysts offers a powerful platform to address synthetic challenges in chemistry, particularly in synthetic cascades. However, transferring both catalysts into organic solvents remains technically difficult because of the enzyme inactivation and catalyst precipitation. Herein, we designed a facile approach using functionalized mesoporous silica nanoparticles (MSN) to transfer chemo- and biocatalysts into a variety of organic solvents. As a proof-of-concept, two distinct catalysts, palladium nanoparticles (Pd NPs) and Candida antarctica lipase B (CalB), were stepwise loaded into separate locations of the mesoporous structure, which not only provided catalysts with heterogeneous supports for the recycling but also avoided their mutual inactivation. Moreover, mesoporous particles were hydrophobized by surface alkylation, resulting in a tailor-made particle hydrophobicity, which allowed bifunctional catalysts to be dispersed in eight organic solvents. Eventually, these attractive material properties provided the MSN-based bifunctional catalysts with remarkable catalytic performance for cascade reaction synthesizing benzyl hexanoate in toluene. With a broader perspective, the success of this study opens new avenues in the field of multifunctional catalysts where a plethora of other chemo- and biocatalysts can be incorporated into surface-functionalized materials ranging from soft matters to porous networks for synthetic purposes in organic solvents.
KW - cascade reaction
KW - lipase CalB
KW - mesoporous silica nanoparticles (MSN)
KW - multifunctional biocatalyst
KW - palladium nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85060793225&partnerID=8YFLogxK
U2 - 10.1021/acsanm.8b01572
DO - 10.1021/acsanm.8b01572
M3 - Article
AN - SCOPUS:85060793225
VL - 1
SP - 6378
EP - 6386
JO - ACS Applied Nano Materials
JF - ACS Applied Nano Materials
IS - 11
ER -