Details
| Original language | English |
|---|---|
| Article number | 38 |
| Journal | npj Science of Food |
| Volume | 8 |
| Issue number | 1 |
| Publication status | Published - 21 Jun 2024 |
Abstract
Sugar beverages are discussed as critical in the development of metabolic endotoxemia. Here, employing a cross-over design study we assessed the effect of diluted cloudy apple juice (AJ), an iso-caloric and -sweetened placebo (P), or water (W) on post-prandial endotoxemia in healthy, normal weight adults. After obtaining fasting blood, 19 healthy men and women consumed 500 mL AJ, P, or W in a randomized order and blood was taken 120 and 180 min later. Caco-2 cells were incubated with the beverages. Markers of intestinal barrier function were assessed. The intake of P but not of AJ or W was associated with a significant increase in TLR2 ligands and bacterial endotoxin in serum after 120 min and 180 min, respectively. P but not AJ significantly increased bacterial toxin permeation in Caco-2 cells. Our results suggest that the effects of sugar-sweetened beverages on markers of intestinal barrier function markedly differ from those of fruit juices.
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Food Science
- Medicine(all)
- Public Health, Environmental and Occupational Health
Sustainable Development Goals
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In: npj Science of Food, Vol. 8, No. 1, 38, 21.06.2024.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Sugar-sweetened beverage but not diluted cloudy apple juice consumption induces post-prandial endotoxemia in healthy adults
AU - Staltner, Raphaela
AU - Valder, Sarah
AU - Wodak, Maximilian F.
AU - Köpsel, Magdalena
AU - Herdegen, Volker
AU - Esatbeyoglu, Tuba
AU - Kostov, Tihomir
AU - Diel, Patrick
AU - Bergheim, Ina
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024/6/21
Y1 - 2024/6/21
N2 - Sugar beverages are discussed as critical in the development of metabolic endotoxemia. Here, employing a cross-over design study we assessed the effect of diluted cloudy apple juice (AJ), an iso-caloric and -sweetened placebo (P), or water (W) on post-prandial endotoxemia in healthy, normal weight adults. After obtaining fasting blood, 19 healthy men and women consumed 500 mL AJ, P, or W in a randomized order and blood was taken 120 and 180 min later. Caco-2 cells were incubated with the beverages. Markers of intestinal barrier function were assessed. The intake of P but not of AJ or W was associated with a significant increase in TLR2 ligands and bacterial endotoxin in serum after 120 min and 180 min, respectively. P but not AJ significantly increased bacterial toxin permeation in Caco-2 cells. Our results suggest that the effects of sugar-sweetened beverages on markers of intestinal barrier function markedly differ from those of fruit juices.
AB - Sugar beverages are discussed as critical in the development of metabolic endotoxemia. Here, employing a cross-over design study we assessed the effect of diluted cloudy apple juice (AJ), an iso-caloric and -sweetened placebo (P), or water (W) on post-prandial endotoxemia in healthy, normal weight adults. After obtaining fasting blood, 19 healthy men and women consumed 500 mL AJ, P, or W in a randomized order and blood was taken 120 and 180 min later. Caco-2 cells were incubated with the beverages. Markers of intestinal barrier function were assessed. The intake of P but not of AJ or W was associated with a significant increase in TLR2 ligands and bacterial endotoxin in serum after 120 min and 180 min, respectively. P but not AJ significantly increased bacterial toxin permeation in Caco-2 cells. Our results suggest that the effects of sugar-sweetened beverages on markers of intestinal barrier function markedly differ from those of fruit juices.
UR - http://www.scopus.com/inward/record.url?scp=85196518777&partnerID=8YFLogxK
U2 - 10.1038/s41538-024-00283-w
DO - 10.1038/s41538-024-00283-w
M3 - Article
AN - SCOPUS:85196518777
VL - 8
JO - npj Science of Food
JF - npj Science of Food
IS - 1
M1 - 38
ER -