Details
| Original language | English |
|---|---|
| Pages (from-to) | 664-670 |
| Number of pages | 7 |
| Journal | Biochimica et Biophysica Acta - Bioenergetics |
| Volume | 1797 |
| Issue number | 6-7 |
| Publication status | Published - 28 Dec 2010 |
Abstract
The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I, III and IV and in a dimeric form of complex V, between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed.
Keywords
- ATP synthase, Electron microscopy, Mitochondria, Oxidative phosphorylation, Respirasome, Supercomplex
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biophysics
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
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In: Biochimica et Biophysica Acta - Bioenergetics, Vol. 1797, No. 6-7, 28.12.2010, p. 664-670.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Structure and function of mitochondrial supercomplexes
AU - Dudkina, Natalya V.
AU - Kouřil, Roman
AU - Peters, Katrin
AU - Braun, Hans Peter
AU - Boekema, Egbert J.
N1 - Funding information: We thank Mr. Jelle Bultema for discussion. This work was supported by the Netherlands organization of scientific research (NWO) and by the Deutsche Forschungsgemeinschaft (grant Br 1829-8/1 ).
PY - 2010/12/28
Y1 - 2010/12/28
N2 - The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I, III and IV and in a dimeric form of complex V, between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed.
AB - The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I, III and IV and in a dimeric form of complex V, between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed.
KW - ATP synthase
KW - Electron microscopy
KW - Mitochondria
KW - Oxidative phosphorylation
KW - Respirasome
KW - Supercomplex
UR - http://www.scopus.com/inward/record.url?scp=77953743759&partnerID=8YFLogxK
U2 - 10.1016/j.bbabio.2009.12.013
DO - 10.1016/j.bbabio.2009.12.013
M3 - Review article
C2 - 20036212
AN - SCOPUS:77953743759
VL - 1797
SP - 664
EP - 670
JO - Biochimica et Biophysica Acta - Bioenergetics
JF - Biochimica et Biophysica Acta - Bioenergetics
SN - 0005-2728
IS - 6-7
ER -