Details
| Original language | English |
|---|---|
| Pages (from-to) | 1235-1240 |
| Number of pages | 6 |
| Journal | Journal of natural products |
| Volume | 80 |
| Issue number | 5 |
| Publication status | Published - 26 May 2017 |
Abstract
The structure of the fungal phytotoxins known as the phyllostictines has been revised to a series of bicyclic 3-methylene tetramic acids. Genome sequencing of the producing organism Phyllostica cirsii has revealed a biosynthetic gene cluster responsible for the biosynthesis of the phyllostictines, and targeted knockout experiments have proven the link and produced an intermediate.
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Medicine(all)
- Complementary and alternative medicine
- Chemistry(all)
- Organic Chemistry
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In: Journal of natural products, Vol. 80, No. 5, 26.05.2017, p. 1235-1240.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Structural Revision and Biosynthesis of the Fungal Phytotoxins Phyllostictines A and B
AU - Trenti, Francesco
AU - Cox, Russell J.
PY - 2017/5/26
Y1 - 2017/5/26
N2 - The structure of the fungal phytotoxins known as the phyllostictines has been revised to a series of bicyclic 3-methylene tetramic acids. Genome sequencing of the producing organism Phyllostica cirsii has revealed a biosynthetic gene cluster responsible for the biosynthesis of the phyllostictines, and targeted knockout experiments have proven the link and produced an intermediate.
AB - The structure of the fungal phytotoxins known as the phyllostictines has been revised to a series of bicyclic 3-methylene tetramic acids. Genome sequencing of the producing organism Phyllostica cirsii has revealed a biosynthetic gene cluster responsible for the biosynthesis of the phyllostictines, and targeted knockout experiments have proven the link and produced an intermediate.
UR - http://www.scopus.com/inward/record.url?scp=85019715951&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.7b00183
DO - 10.1021/acs.jnatprod.7b00183
M3 - Article
C2 - 28467083
AN - SCOPUS:85019715951
VL - 80
SP - 1235
EP - 1240
JO - Journal of natural products
JF - Journal of natural products
SN - 0163-3864
IS - 5
ER -