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Translated title of the contribution | Bestimmung der relativen und absoluten Konfiguration von Thuggacin A–C, hochaktiven Antibiotika aus dem Myxobakterium Sorangium cellulosum |
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Original language | English |
Pages (from-to) | 2308-2311 |
Number of pages | 4 |
Journal | Angewandte Chemie |
Volume | 47 |
Issue number | 12 |
Publication status | Published - 3 Mar 2008 |
Abstract
Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A-C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes. (Chemical Equation Presented).
Keywords
- Antibiotics, Gene analysis, Macrolactones, Mosher ester, Structure elucidation
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: Angewandte Chemie , Vol. 47, No. 12, 03.03.2008, p. 2308-2311.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Stereochemical determination of thuggacins A-C, highly active antibiotics from the myxobacterium Sorangium cellulosum
AU - Bock, Martin
AU - Buntin, Kathrin
AU - Müller, Rolf
AU - Kirschning, Andreas
PY - 2008/3/3
Y1 - 2008/3/3
N2 - Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A-C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes. (Chemical Equation Presented).
AB - Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A-C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes. (Chemical Equation Presented).
KW - Antibiotics
KW - Gene analysis
KW - Macrolactones
KW - Mosher ester
KW - Structure elucidation
UR - http://www.scopus.com/inward/record.url?scp=41049118134&partnerID=8YFLogxK
U2 - 10.1002/anie.200704897
DO - 10.1002/anie.200704897
M3 - Article
C2 - 18275054
AN - SCOPUS:41049118134
VL - 47
SP - 2308
EP - 2311
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 12
ER -