Stereo Laryngoscopic Impact Site Prediction for Droplet-Based Stimulation of the Laryngeal Adductor Reflex

Research output: Contribution to journal › Article › Research › peer review

Authors

  • Jacob Friedemann Fast
  • Hardik Dava
  • Adrian Karl Rüppel
  • Dennis Kundrat
  • Maurice Krauth
  • Max-Heinrich Viktor Laves
  • Svenja Spindeldreier
  • Lüder Alexander Kahrs
  • Martin Ptok

Research Organisations

External Research Organisations

  • Hannover Medical School (MHH)
  • Hamburg University of Technology (TUHH)
  • Hospital for Sick Children University of Toronto
View graph of relations

Details

Original languageEnglish
Pages (from-to)112177 - 112192
Number of pages16
JournalIEEE Access
Volume9
Publication statusPublished - 6 Aug 2021

Abstract

The laryngeal adductor reflex (LAR) is a vital reflex of the human larynx. LAR malfunctions may cause life-threatening aspiration events. An objective, noninvasive, and reproducible method for LAR assessment is still lacking. Stimulation of the larynx by droplet impact, termed Microdroplet Impulse Testing of the LAR (MIT-LAR), may remedy this situation. However, droplet instability and imprecise stimulus application thus far prevented MIT-LAR from gaining clinical relevance. We present a system comprising two alternative, custom-built stereo laryngoscopes, each offering a distinct set of properties, a droplet applicator module, and image/point cloud processing algorithms to enable a targeted, droplet-based LAR stimulation. Droplet impact site prediction (ISP) is achieved by droplet trajectory identification and spatial target reconstruction. The reconstruction and ISP accuracies were experimentally evaluated. Global spatial reconstruction errors at the glottal area of (0.3±0.3) mm and (0.4±0.3) mm and global ISP errors of (0.9±0.6) mm and (1.3±0.8) mm were found for a rod lens-based and an alternative, fiberoptic laryngoscope, respectively. In the case of the rod lens-based system, 96% of all observed ISP error values are inferior to 2 mm; a value of 80% was found with the fiberoptic assembly. This contribution represents an important step towards introducing a reproducible and objective LAR screening method into the clinical routine.

Keywords

    Aspiration, biomedical engineering, computer aided diagnosis, endoscopes, image guidance, laryngeal closure reflex, reflex latency, stereo endoscopy

ASJC Scopus subject areas

Cite this

Stereo Laryngoscopic Impact Site Prediction for Droplet-Based Stimulation of the Laryngeal Adductor Reflex. / Fast, Jacob Friedemann; Dava, Hardik; Rüppel, Adrian Karl et al.
In: IEEE Access, Vol. 9, 06.08.2021, p. 112177 - 112192.

Research output: Contribution to journal › Article › Research › peer review

Fast, JF, Dava, H, Rüppel, AK, Kundrat, D, Krauth, M, Laves, M-HV, Spindeldreier, S, Kahrs, LA & Ptok, M 2021, 'Stereo Laryngoscopic Impact Site Prediction for Droplet-Based Stimulation of the Laryngeal Adductor Reflex', IEEE Access, vol. 9, pp. 112177 - 112192. https://doi.org/10.1109/ACCESS.2021.3103049
Fast, J. F., Dava, H., Rüppel, A. K., Kundrat, D., Krauth, M., Laves, M.-H. V., Spindeldreier, S., Kahrs, L. A., & Ptok, M. (2021). Stereo Laryngoscopic Impact Site Prediction for Droplet-Based Stimulation of the Laryngeal Adductor Reflex. IEEE Access, 9, 112177 - 112192. https://doi.org/10.1109/ACCESS.2021.3103049
Fast JF, Dava H, Rüppel AK, Kundrat D, Krauth M, Laves MHV et al. Stereo Laryngoscopic Impact Site Prediction for Droplet-Based Stimulation of the Laryngeal Adductor Reflex. IEEE Access. 2021 Aug 6;9:112177 - 112192. doi: 10.1109/ACCESS.2021.3103049
Fast, Jacob Friedemann ; Dava, Hardik ; Rüppel, Adrian Karl et al. / Stereo Laryngoscopic Impact Site Prediction for Droplet-Based Stimulation of the Laryngeal Adductor Reflex. In: IEEE Access. 2021 ; Vol. 9. pp. 112177 - 112192.
Download
@article{8e5f3feda7194ade98362d273570dbd7,
title = "Stereo Laryngoscopic Impact Site Prediction for Droplet-Based Stimulation of the Laryngeal Adductor Reflex",
abstract = "The laryngeal adductor reflex (LAR) is a vital reflex of the human larynx. LAR malfunctions may cause life-threatening aspiration events. An objective, noninvasive, and reproducible method for LAR assessment is still lacking. Stimulation of the larynx by droplet impact, termed Microdroplet Impulse Testing of the LAR (MIT-LAR), may remedy this situation. However, droplet instability and imprecise stimulus application thus far prevented MIT-LAR from gaining clinical relevance. We present a system comprising two alternative, custom-built stereo laryngoscopes, each offering a distinct set of properties, a droplet applicator module, and image/point cloud processing algorithms to enable a targeted, droplet-based LAR stimulation. Droplet impact site prediction (ISP) is achieved by droplet trajectory identification and spatial target reconstruction. The reconstruction and ISP accuracies were experimentally evaluated. Global spatial reconstruction errors at the glottal area of (0.3±0.3) mm and (0.4±0.3) mm and global ISP errors of (0.9±0.6) mm and (1.3±0.8) mm were found for a rod lens-based and an alternative, fiberoptic laryngoscope, respectively. In the case of the rod lens-based system, 96% of all observed ISP error values are inferior to 2 mm; a value of 80% was found with the fiberoptic assembly. This contribution represents an important step towards introducing a reproducible and objective LAR screening method into the clinical routine.",
keywords = "Aspiration, biomedical engineering, computer aided diagnosis, endoscopes, image guidance, laryngeal closure reflex, reflex latency, stereo endoscopy",
author = "Fast, {Jacob Friedemann} and Hardik Dava and R{\"u}ppel, {Adrian Karl} and Dennis Kundrat and Maurice Krauth and Laves, {Max-Heinrich Viktor} and Svenja Spindeldreier and Kahrs, {L{\"u}der Alexander} and Martin Ptok",
note = "Funding Information: This work was supported by German Research Foundation under Grant KA 2975/6-1 and Grant PT 2/5-1.",
year = "2021",
month = aug,
day = "6",
doi = "10.1109/ACCESS.2021.3103049",
language = "English",
volume = "9",
pages = "112177 -- 112192",
journal = "IEEE Access",
issn = "2169-3536",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

Download

TY - JOUR

T1 - Stereo Laryngoscopic Impact Site Prediction for Droplet-Based Stimulation of the Laryngeal Adductor Reflex

AU - Fast, Jacob Friedemann

AU - Dava, Hardik

AU - Rüppel, Adrian Karl

AU - Kundrat, Dennis

AU - Krauth, Maurice

AU - Laves, Max-Heinrich Viktor

AU - Spindeldreier, Svenja

AU - Kahrs, Lüder Alexander

AU - Ptok, Martin

N1 - Funding Information: This work was supported by German Research Foundation under Grant KA 2975/6-1 and Grant PT 2/5-1.

PY - 2021/8/6

Y1 - 2021/8/6

N2 - The laryngeal adductor reflex (LAR) is a vital reflex of the human larynx. LAR malfunctions may cause life-threatening aspiration events. An objective, noninvasive, and reproducible method for LAR assessment is still lacking. Stimulation of the larynx by droplet impact, termed Microdroplet Impulse Testing of the LAR (MIT-LAR), may remedy this situation. However, droplet instability and imprecise stimulus application thus far prevented MIT-LAR from gaining clinical relevance. We present a system comprising two alternative, custom-built stereo laryngoscopes, each offering a distinct set of properties, a droplet applicator module, and image/point cloud processing algorithms to enable a targeted, droplet-based LAR stimulation. Droplet impact site prediction (ISP) is achieved by droplet trajectory identification and spatial target reconstruction. The reconstruction and ISP accuracies were experimentally evaluated. Global spatial reconstruction errors at the glottal area of (0.3±0.3) mm and (0.4±0.3) mm and global ISP errors of (0.9±0.6) mm and (1.3±0.8) mm were found for a rod lens-based and an alternative, fiberoptic laryngoscope, respectively. In the case of the rod lens-based system, 96% of all observed ISP error values are inferior to 2 mm; a value of 80% was found with the fiberoptic assembly. This contribution represents an important step towards introducing a reproducible and objective LAR screening method into the clinical routine.

AB - The laryngeal adductor reflex (LAR) is a vital reflex of the human larynx. LAR malfunctions may cause life-threatening aspiration events. An objective, noninvasive, and reproducible method for LAR assessment is still lacking. Stimulation of the larynx by droplet impact, termed Microdroplet Impulse Testing of the LAR (MIT-LAR), may remedy this situation. However, droplet instability and imprecise stimulus application thus far prevented MIT-LAR from gaining clinical relevance. We present a system comprising two alternative, custom-built stereo laryngoscopes, each offering a distinct set of properties, a droplet applicator module, and image/point cloud processing algorithms to enable a targeted, droplet-based LAR stimulation. Droplet impact site prediction (ISP) is achieved by droplet trajectory identification and spatial target reconstruction. The reconstruction and ISP accuracies were experimentally evaluated. Global spatial reconstruction errors at the glottal area of (0.3±0.3) mm and (0.4±0.3) mm and global ISP errors of (0.9±0.6) mm and (1.3±0.8) mm were found for a rod lens-based and an alternative, fiberoptic laryngoscope, respectively. In the case of the rod lens-based system, 96% of all observed ISP error values are inferior to 2 mm; a value of 80% was found with the fiberoptic assembly. This contribution represents an important step towards introducing a reproducible and objective LAR screening method into the clinical routine.

KW - Aspiration

KW - biomedical engineering

KW - computer aided diagnosis

KW - endoscopes

KW - image guidance

KW - laryngeal closure reflex

KW - reflex latency

KW - stereo endoscopy

UR - http://www.scopus.com/inward/record.url?scp=85112160054&partnerID=8YFLogxK

U2 - 10.1109/ACCESS.2021.3103049

DO - 10.1109/ACCESS.2021.3103049

M3 - Article

VL - 9

SP - 112177

EP - 112192

JO - IEEE Access

JF - IEEE Access

SN - 2169-3536

ER -