Details
| Original language | English |
|---|---|
| Pages (from-to) | 1289-1293 |
| Number of pages | 5 |
| Journal | Synlett |
| Issue number | 9 |
| Publication status | Published - 2000 |
| Externally published | Yes |
Abstract
Two polymeric supports along with two different linkers for attachment to O-4 of carbohydrate-derived glycals were evaluated for the solid phase synthesis of new glycosteroids 9 and 16. From these studies it can be concluded that soluble MPEG-ethers are less well suited polymeric supports for automated synthesis of glycoconjugates. Furthermore, it was found that glycosylation proceeds with much higher selectivity with polymer-bound glycals 3a and 12 compared to the solution variant.
Keywords
- Glycosteroid, Linker, Natural product, Solid phase synthesis
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
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In: Synlett, No. 9, 2000, p. 1289-1293.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Soluble versus insoluble polymers as supports for the preparation of new glycosteroids
T2 - A practicability study
AU - Jesberger, Martin
AU - Jaunzems, Janis
AU - Jung, A.
AU - Jas, Gerhard
AU - Schönberger, Andreas
AU - Kirschning, Andreas
PY - 2000
Y1 - 2000
N2 - Two polymeric supports along with two different linkers for attachment to O-4 of carbohydrate-derived glycals were evaluated for the solid phase synthesis of new glycosteroids 9 and 16. From these studies it can be concluded that soluble MPEG-ethers are less well suited polymeric supports for automated synthesis of glycoconjugates. Furthermore, it was found that glycosylation proceeds with much higher selectivity with polymer-bound glycals 3a and 12 compared to the solution variant.
AB - Two polymeric supports along with two different linkers for attachment to O-4 of carbohydrate-derived glycals were evaluated for the solid phase synthesis of new glycosteroids 9 and 16. From these studies it can be concluded that soluble MPEG-ethers are less well suited polymeric supports for automated synthesis of glycoconjugates. Furthermore, it was found that glycosylation proceeds with much higher selectivity with polymer-bound glycals 3a and 12 compared to the solution variant.
KW - Glycosteroid
KW - Linker
KW - Natural product
KW - Solid phase synthesis
UR - http://www.scopus.com/inward/record.url?scp=0033799934&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0033799934
SP - 1289
EP - 1293
JO - Synlett
JF - Synlett
SN - 0936-5214
IS - 9
ER -