Details
| Original language | English |
|---|---|
| Pages (from-to) | 5544-5554 |
| Number of pages | 11 |
| Journal | ACS Applied Polymer Materials |
| Volume | 6 |
| Issue number | 9 |
| Early online date | 23 Apr 2024 |
| Publication status | Published - 10 May 2024 |
Abstract
Stimulus-responsive (smart) hydrogels are a promising sensing material for biomedical contexts due to their reversible swelling change in response to target analytes. The design of application-specific sensors that utilize this behavior requires the development of suitable transduction concepts. The presented study investigates a power-transfer-based readout approach that is sensitive to small volumetric changes of the smart hydrogel. The concept employs two thin film polyimide substrates with embedded conductive strip lines, which are shielded from each other except at the tip region, where the smart hydrogel is sandwiched in between. The hydrogel’s volume change in response to a target analyte alters the distance and orientation of the thin films, affecting the amount of transferred power between the two transducer parts and, consequently, the measured sensor output voltage. With proper calibration, the output signal can be used to determine the swelling change of the hydrogel and, consequently, to quantify the stimulus. In proof-of-principle experiments with glucose- and pH-sensitive smart hydrogels, high sensitivity to small analyte concentration changes was found along with very good reproducibility and stability. The concept was tested with two exemplary hydrogels, but the transduction principle in general is independent of the specific hydrogel material, as long as it exhibits a stimulus-dependent volume change. The application vision of the presented research is to integrate in situ blood analyte monitoring capabilities into standard (micro)catheters. The developed sensor is designed to fit into a catheter without obstructing its normal use and, therefore, offers great potential for providing a universally applicable transducer platform for smart catheter-based sensing.
Keywords
- electromagnetic power transfer, flexible sensors, in situ analyte monitoring, inductive coupling, microcatheter, Stimulus-responsive hydrogel, swelling state transduction
ASJC Scopus subject areas
- Chemical Engineering(all)
- Process Chemistry and Technology
- Materials Science(all)
- Polymers and Plastics
- Chemistry(all)
- Organic Chemistry
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In: ACS Applied Polymer Materials, Vol. 6, No. 9, 10.05.2024, p. 5544-5554.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Smart Hydrogel Swelling State Detection Based on a Power-Transfer Transduction Principle
AU - Ahmed, Benozir
AU - Reiche, Christopher F.
AU - Magda, Jules J.
AU - Solzbacher, Florian
AU - Körner, Julia
N1 - Funding Information: The reported research was supported by the Joe W. and Dorothy Dorsett Brown Foundation, the Olive Tupper Foundation, and the National Institute of General Medical Sciences of the National Institutes of Health (NIH) under Award 1R41GM130241 awarded to Sentiomed, Inc. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the foundations.
PY - 2024/5/10
Y1 - 2024/5/10
N2 - Stimulus-responsive (smart) hydrogels are a promising sensing material for biomedical contexts due to their reversible swelling change in response to target analytes. The design of application-specific sensors that utilize this behavior requires the development of suitable transduction concepts. The presented study investigates a power-transfer-based readout approach that is sensitive to small volumetric changes of the smart hydrogel. The concept employs two thin film polyimide substrates with embedded conductive strip lines, which are shielded from each other except at the tip region, where the smart hydrogel is sandwiched in between. The hydrogel’s volume change in response to a target analyte alters the distance and orientation of the thin films, affecting the amount of transferred power between the two transducer parts and, consequently, the measured sensor output voltage. With proper calibration, the output signal can be used to determine the swelling change of the hydrogel and, consequently, to quantify the stimulus. In proof-of-principle experiments with glucose- and pH-sensitive smart hydrogels, high sensitivity to small analyte concentration changes was found along with very good reproducibility and stability. The concept was tested with two exemplary hydrogels, but the transduction principle in general is independent of the specific hydrogel material, as long as it exhibits a stimulus-dependent volume change. The application vision of the presented research is to integrate in situ blood analyte monitoring capabilities into standard (micro)catheters. The developed sensor is designed to fit into a catheter without obstructing its normal use and, therefore, offers great potential for providing a universally applicable transducer platform for smart catheter-based sensing.
AB - Stimulus-responsive (smart) hydrogels are a promising sensing material for biomedical contexts due to their reversible swelling change in response to target analytes. The design of application-specific sensors that utilize this behavior requires the development of suitable transduction concepts. The presented study investigates a power-transfer-based readout approach that is sensitive to small volumetric changes of the smart hydrogel. The concept employs two thin film polyimide substrates with embedded conductive strip lines, which are shielded from each other except at the tip region, where the smart hydrogel is sandwiched in between. The hydrogel’s volume change in response to a target analyte alters the distance and orientation of the thin films, affecting the amount of transferred power between the two transducer parts and, consequently, the measured sensor output voltage. With proper calibration, the output signal can be used to determine the swelling change of the hydrogel and, consequently, to quantify the stimulus. In proof-of-principle experiments with glucose- and pH-sensitive smart hydrogels, high sensitivity to small analyte concentration changes was found along with very good reproducibility and stability. The concept was tested with two exemplary hydrogels, but the transduction principle in general is independent of the specific hydrogel material, as long as it exhibits a stimulus-dependent volume change. The application vision of the presented research is to integrate in situ blood analyte monitoring capabilities into standard (micro)catheters. The developed sensor is designed to fit into a catheter without obstructing its normal use and, therefore, offers great potential for providing a universally applicable transducer platform for smart catheter-based sensing.
KW - electromagnetic power transfer
KW - flexible sensors
KW - in situ analyte monitoring
KW - inductive coupling
KW - microcatheter
KW - Stimulus-responsive hydrogel
KW - swelling state transduction
UR - http://www.scopus.com/inward/record.url?scp=85191770418&partnerID=8YFLogxK
U2 - 10.1021/acsapm.4c00808
DO - 10.1021/acsapm.4c00808
M3 - Article
AN - SCOPUS:85191770418
VL - 6
SP - 5544
EP - 5554
JO - ACS Applied Polymer Materials
JF - ACS Applied Polymer Materials
IS - 9
ER -