Details
| Original language | English |
|---|---|
| Article number | 2346 |
| Journal | NUTRIENTS |
| Volume | 11 |
| Issue number | 10 |
| Early online date | 2 Oct 2019 |
| Publication status | Published - Oct 2019 |
Abstract
The omega-3 (n3) polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with health benefits. The primary dietary source of EPA and DHA is seafood. Alpha-linoleic acid (ALA) has not been shown to be a good source for EPA and DHA; however, stearidonic acid (SDA)-which is naturally contained in echium oil (EO)-may be a more promising alternative. This study was aimed at investigating the short-term n3 PUFA metabolism after the ingestion of a single dose of EO. Healthy young male subjects (n = 12) ingested a single dose of 26 g of EO after overnight fasting. Plasma fatty acid concentrations and relative amounts were determined at baseline and 2, 4, 6, 8, 24, 48, and 72 h after the ingestion of EO. During the whole examination period, the participants received standardized nutrition. Plasma ALA and SDA concentrations increased rapidly after the single dose of EO. Additionally, EPA and DPAn3 concentrations both increased significantly by 47% after 72 h compared to baseline; DHA concentrations also significantly increased by 21% after 72 h. To conclude, EO increases plasma ALA, SDA, EPA, DPAn3, and DHA concentrations and may be an alternative source for these n3 PUFAs.
Keywords
- Administration, Oral, Adult, Docosahexaenoic Acids/blood, Echium, Eicosapentaenoic Acid/blood, Fatty Acids, Omega-3/administration & dosage, Germany, Humans, Lipid Metabolism, Male, Plant Oils/administration & dosage, Time Factors, Young Adult, alpha-Linolenic Acid/blood, Stearidonic acid, Conversion, Polyunsaturated fatty acid metabolism
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Food Science
- Nursing(all)
- Nutrition and Dietetics
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In: NUTRIENTS, Vol. 11, No. 10, 2346, 10.2019.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations
AU - Greupner, Theresa
AU - Koch, Elisabeth
AU - Kutzner, Laura
AU - Hahn, Andreas
AU - Schebb, Nils Helge
AU - Schuchardt, Jan Philipp
N1 - Funding information: This research was funded by DFG, grant number SCHU 2516, SCHE 1801. Acknowledgments: This study was supported by grants from the German Research Foundation (Grant SCHE 1801 and SCHU 2516) to NHS and JPS. We would like to thank the participants who contributed their time to this project and Sarah Reuber, Sebastian Biernacki and Mustafa Bagci for assisting the GC analysis. The publication of this article was funded by the Open Access fund of Leibniz Universität Hannover.
PY - 2019/10
Y1 - 2019/10
N2 - The omega-3 (n3) polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with health benefits. The primary dietary source of EPA and DHA is seafood. Alpha-linoleic acid (ALA) has not been shown to be a good source for EPA and DHA; however, stearidonic acid (SDA)-which is naturally contained in echium oil (EO)-may be a more promising alternative. This study was aimed at investigating the short-term n3 PUFA metabolism after the ingestion of a single dose of EO. Healthy young male subjects (n = 12) ingested a single dose of 26 g of EO after overnight fasting. Plasma fatty acid concentrations and relative amounts were determined at baseline and 2, 4, 6, 8, 24, 48, and 72 h after the ingestion of EO. During the whole examination period, the participants received standardized nutrition. Plasma ALA and SDA concentrations increased rapidly after the single dose of EO. Additionally, EPA and DPAn3 concentrations both increased significantly by 47% after 72 h compared to baseline; DHA concentrations also significantly increased by 21% after 72 h. To conclude, EO increases plasma ALA, SDA, EPA, DPAn3, and DHA concentrations and may be an alternative source for these n3 PUFAs.
AB - The omega-3 (n3) polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with health benefits. The primary dietary source of EPA and DHA is seafood. Alpha-linoleic acid (ALA) has not been shown to be a good source for EPA and DHA; however, stearidonic acid (SDA)-which is naturally contained in echium oil (EO)-may be a more promising alternative. This study was aimed at investigating the short-term n3 PUFA metabolism after the ingestion of a single dose of EO. Healthy young male subjects (n = 12) ingested a single dose of 26 g of EO after overnight fasting. Plasma fatty acid concentrations and relative amounts were determined at baseline and 2, 4, 6, 8, 24, 48, and 72 h after the ingestion of EO. During the whole examination period, the participants received standardized nutrition. Plasma ALA and SDA concentrations increased rapidly after the single dose of EO. Additionally, EPA and DPAn3 concentrations both increased significantly by 47% after 72 h compared to baseline; DHA concentrations also significantly increased by 21% after 72 h. To conclude, EO increases plasma ALA, SDA, EPA, DPAn3, and DHA concentrations and may be an alternative source for these n3 PUFAs.
KW - Administration, Oral
KW - Adult
KW - Docosahexaenoic Acids/blood
KW - Echium
KW - Eicosapentaenoic Acid/blood
KW - Fatty Acids, Omega-3/administration & dosage
KW - Germany
KW - Humans
KW - Lipid Metabolism
KW - Male
KW - Plant Oils/administration & dosage
KW - Time Factors
KW - Young Adult
KW - alpha-Linolenic Acid/blood
KW - Stearidonic acid
KW - Conversion
KW - Polyunsaturated fatty acid metabolism
UR - http://www.scopus.com/inward/record.url?scp=85072911453&partnerID=8YFLogxK
U2 - 10.3390/nu11102346
DO - 10.3390/nu11102346
M3 - Article
C2 - 31581725
VL - 11
JO - NUTRIENTS
JF - NUTRIENTS
SN - 2072-6643
IS - 10
M1 - 2346
ER -