Details
| Original language | English |
|---|---|
| Pages (from-to) | 591-597 |
| Number of pages | 7 |
| Journal | Therapeutic Innovation & Regulatory Science |
| Volume | 34 |
| Issue number | 2 |
| Publication status | Published - 30 Dec 2000 |
Abstract
For the analysis of dose-response relationship under the assumption of ordered alternatives several global trend tests are available. Furthermore, there are multiple test procedures which can identify doses as effective or even as minimally effective. In this paper it is shown that the principles of multiple comparisons and interim analyses can be combined inflexible and adaptive strategies for dose-response analyses; these procedures control the experimentwise error rate.
Keywords
- Dose-response, Interim analysis, Multiple testing
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Medicine(all)
- Pharmacology (medical)
Sustainable Development Goals
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In: Therapeutic Innovation & Regulatory Science, Vol. 34, No. 2, 30.12.2000, p. 591-597.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Sequential and Multiple Testing for Dose-Response Analysis
AU - Lehmacher, Walter
AU - Kieser, Meinhard
AU - Hothorn, Ludwig
PY - 2000/12/30
Y1 - 2000/12/30
N2 - For the analysis of dose-response relationship under the assumption of ordered alternatives several global trend tests are available. Furthermore, there are multiple test procedures which can identify doses as effective or even as minimally effective. In this paper it is shown that the principles of multiple comparisons and interim analyses can be combined inflexible and adaptive strategies for dose-response analyses; these procedures control the experimentwise error rate.
AB - For the analysis of dose-response relationship under the assumption of ordered alternatives several global trend tests are available. Furthermore, there are multiple test procedures which can identify doses as effective or even as minimally effective. In this paper it is shown that the principles of multiple comparisons and interim analyses can be combined inflexible and adaptive strategies for dose-response analyses; these procedures control the experimentwise error rate.
KW - Dose-response
KW - Interim analysis
KW - Multiple testing
UR - http://www.scopus.com/inward/record.url?scp=84996248859&partnerID=8YFLogxK
U2 - 10.1177/009286150003400227
DO - 10.1177/009286150003400227
M3 - Article
AN - SCOPUS:84996248859
VL - 34
SP - 591
EP - 597
JO - Therapeutic Innovation & Regulatory Science
JF - Therapeutic Innovation & Regulatory Science
SN - 2168-4790
IS - 2
ER -