Details
| Original language | English |
|---|---|
| Pages (from-to) | 1509-1515 |
| Number of pages | 7 |
| Journal | Analytical chemistry |
| Volume | 89 |
| Issue number | 3 |
| Early online date | 12 Jan 2017 |
| Publication status | Published - 7 Feb 2017 |
Abstract
Ion mobility spectrometry provides ion separation in the gas phase mainly based on differing ion-neutral collision cross sections, enabling powerful analysis of many isomers. However, the separation also has a miniscule mass dependence due to the acceleration and collision properties. In this work, we show for the first time that using a compact ultra-high-resolution ion mobility spectrometer with a resolving power of 250 and an UV ionization source enables the separation of isotopologues with ion mobility spectrometry. This is demonstrated for regular and perdeuterated acetone, benzene, and toluene as well as toluene-13C7 in nitrogen and in purified air as drift gas. The observed peak shifts in the ion mobility spectrum agree with the basic ion mobility equation when using nitrogen as drift gas and also agree with a combination of this equation with Blanc's law when using purified air as drift gas. For benzene and toluene, a reduction in the ion-neutral collision cross section of the isotopically replaced species is observed. Furthermore, a third peak formed from regular and perdeuterated acetone is observed, which can most likely be attributed to the exchange of a methyl group. (Graph Presented).
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Analytical chemistry, Vol. 89, No. 3, 07.02.2017, p. 1509-1515.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Separation of Isotopologues in Ultra-High-Resolution Ion Mobility Spectrometry
AU - Kirk, Ansgar T.
AU - Raddatz, Christian-Robert
AU - Zimmermann, Stefan
N1 - Funding Information: We thank Alexander Bohnhorst for his help in setting up the automated data analysis. Furthermore, we thank numerous participants of the ISIMS conference 2016 in Boston for very insightful discussions. This work was funded by the German Research Foundation (DFG).
PY - 2017/2/7
Y1 - 2017/2/7
N2 - Ion mobility spectrometry provides ion separation in the gas phase mainly based on differing ion-neutral collision cross sections, enabling powerful analysis of many isomers. However, the separation also has a miniscule mass dependence due to the acceleration and collision properties. In this work, we show for the first time that using a compact ultra-high-resolution ion mobility spectrometer with a resolving power of 250 and an UV ionization source enables the separation of isotopologues with ion mobility spectrometry. This is demonstrated for regular and perdeuterated acetone, benzene, and toluene as well as toluene-13C7 in nitrogen and in purified air as drift gas. The observed peak shifts in the ion mobility spectrum agree with the basic ion mobility equation when using nitrogen as drift gas and also agree with a combination of this equation with Blanc's law when using purified air as drift gas. For benzene and toluene, a reduction in the ion-neutral collision cross section of the isotopically replaced species is observed. Furthermore, a third peak formed from regular and perdeuterated acetone is observed, which can most likely be attributed to the exchange of a methyl group. (Graph Presented).
AB - Ion mobility spectrometry provides ion separation in the gas phase mainly based on differing ion-neutral collision cross sections, enabling powerful analysis of many isomers. However, the separation also has a miniscule mass dependence due to the acceleration and collision properties. In this work, we show for the first time that using a compact ultra-high-resolution ion mobility spectrometer with a resolving power of 250 and an UV ionization source enables the separation of isotopologues with ion mobility spectrometry. This is demonstrated for regular and perdeuterated acetone, benzene, and toluene as well as toluene-13C7 in nitrogen and in purified air as drift gas. The observed peak shifts in the ion mobility spectrum agree with the basic ion mobility equation when using nitrogen as drift gas and also agree with a combination of this equation with Blanc's law when using purified air as drift gas. For benzene and toluene, a reduction in the ion-neutral collision cross section of the isotopically replaced species is observed. Furthermore, a third peak formed from regular and perdeuterated acetone is observed, which can most likely be attributed to the exchange of a methyl group. (Graph Presented).
UR - http://www.scopus.com/inward/record.url?scp=85017561877&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.6b03300
DO - 10.1021/acs.analchem.6b03300
M3 - Article
C2 - 28208278
AN - SCOPUS:85017561877
VL - 89
SP - 1509
EP - 1515
JO - Analytical chemistry
JF - Analytical chemistry
SN - 0003-2700
IS - 3
ER -