Details
| Original language | English |
|---|---|
| Pages (from-to) | 940-952 |
| Number of pages | 13 |
| Journal | Engineering in life sciences |
| Volume | 17 |
| Issue number | 8 |
| Publication status | Published - Aug 2017 |
Abstract
Modern bioprocess monitoring demands sensors that provide on-line information about the process state. In particular, sensors for monitoring bioprocesses carried out in single-use bioreactors are needed because disposable systems are becoming increasingly important for biotechnological applications. Requirements for the sensors used in these single-use bioreactors are different than those used in classical reusable bioreactors. For example, long lifetime or resistance to steam and cleaning procedures are less crucial factors, while a requirement of sensors for disposable bioreactors is a cost that is reasonable on a per-use basis. Here, we present an overview of current and emerging sensors for single-use bioreactors, organized by the type of interface of the sensor systems to the bioreactor. A major focus is on non-invasive, in-situ sensors that are based on electromagnetic, semiconducting, optical, or ultrasonic measurements. In addition, new technologies like radio-frequency identification sensors or free-floating sensor spheres are presented. Notably, at this time there is no standard interface between single-use bioreactors and the sensors discussed here. In the future, manufacturers should address this shortcoming to promote single-use bioprocess monitoring and control.
Keywords
- Bioprocess monitoring, Disposable bioreactors, Disposable sensors, Process analytical technology, Process control, Sensor systems, Single-use
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Environmental Science(all)
- Environmental Engineering
- Chemical Engineering(all)
- Bioengineering
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In: Engineering in life sciences, Vol. 17, No. 8, 08.2017, p. 940-952.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Sensors for disposable bioreactors
AU - Busse, Christoph
AU - Biechele, Philipp
AU - de Vries, Ingo
AU - Reardon, Kenneth F.
AU - Solle, Dörte
AU - Scheper, Thomas
PY - 2017/8
Y1 - 2017/8
N2 - Modern bioprocess monitoring demands sensors that provide on-line information about the process state. In particular, sensors for monitoring bioprocesses carried out in single-use bioreactors are needed because disposable systems are becoming increasingly important for biotechnological applications. Requirements for the sensors used in these single-use bioreactors are different than those used in classical reusable bioreactors. For example, long lifetime or resistance to steam and cleaning procedures are less crucial factors, while a requirement of sensors for disposable bioreactors is a cost that is reasonable on a per-use basis. Here, we present an overview of current and emerging sensors for single-use bioreactors, organized by the type of interface of the sensor systems to the bioreactor. A major focus is on non-invasive, in-situ sensors that are based on electromagnetic, semiconducting, optical, or ultrasonic measurements. In addition, new technologies like radio-frequency identification sensors or free-floating sensor spheres are presented. Notably, at this time there is no standard interface between single-use bioreactors and the sensors discussed here. In the future, manufacturers should address this shortcoming to promote single-use bioprocess monitoring and control.
AB - Modern bioprocess monitoring demands sensors that provide on-line information about the process state. In particular, sensors for monitoring bioprocesses carried out in single-use bioreactors are needed because disposable systems are becoming increasingly important for biotechnological applications. Requirements for the sensors used in these single-use bioreactors are different than those used in classical reusable bioreactors. For example, long lifetime or resistance to steam and cleaning procedures are less crucial factors, while a requirement of sensors for disposable bioreactors is a cost that is reasonable on a per-use basis. Here, we present an overview of current and emerging sensors for single-use bioreactors, organized by the type of interface of the sensor systems to the bioreactor. A major focus is on non-invasive, in-situ sensors that are based on electromagnetic, semiconducting, optical, or ultrasonic measurements. In addition, new technologies like radio-frequency identification sensors or free-floating sensor spheres are presented. Notably, at this time there is no standard interface between single-use bioreactors and the sensors discussed here. In the future, manufacturers should address this shortcoming to promote single-use bioprocess monitoring and control.
KW - Bioprocess monitoring
KW - Disposable bioreactors
KW - Disposable sensors
KW - Process analytical technology
KW - Process control
KW - Sensor systems
KW - Single-use
UR - http://www.scopus.com/inward/record.url?scp=85028342104&partnerID=8YFLogxK
U2 - 10.1002/elsc.201700049
DO - 10.1002/elsc.201700049
M3 - Review article
AN - SCOPUS:85028342104
VL - 17
SP - 940
EP - 952
JO - Engineering in life sciences
JF - Engineering in life sciences
SN - 1618-0240
IS - 8
ER -