Sensors for disposable bioreactor systems

Research output: Chapter in book/report/conference proceedingContribution to book/anthologyResearchpeer review

Authors

Research Organisations

External Research Organisations

  • Colorado State University
  • Sanofi-Aventis Deutschland GmbH
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Details

Original languageEnglish
Title of host publicationSingle-Use Technology in Biopharmaceutical Manufacture
EditorsRegine Eibl, Dieter Eibl
PublisherWiley-Blackwell
Chapter6
Pages69-82
Number of pages14
Edition2.
ISBN (electronic)9781119477891
ISBN (print)9781119477839
Publication statusPublished - 5 Aug 2019

Abstract

This chapter provides an overview on the available and future sensor technology for single-use bioreactors. A bioreactor can be considered to be a three-phase system, consisting of a liquid, gas, and solid phase (cells). Sensors for monitoring each of these phases exist. However, because of their relevance for disposable bioreactors, the chapter is constrained to sensors for liquid-phase analysis. In the case of liquid-phase online measurements, one can distinguish invasive from noninvasive sensors. Invasive sensors are in direct contact with the cultivation medium, whereas noninvasive systems preserve the integrity of the sterile barrier of the reactor. Optical chemosensors (optodes) enable in situ measurements and can be used as online monitoring devices. Most optodes work with a disposable sensing part and reusable connection and readout unit. Optical chemosensors can easily be integrated into disposable bioreactor systems. The optical window concept can also be used for spectroscopic sensors.

Keywords

    Disposable bioreactor systems, In situ measurements, Invasive sensors, Liquid-phase analysis, Noninvasive sensors, Optical chemosensors, Single-use bioreactors, Spectroscopic sensors

ASJC Scopus subject areas

Cite this

Sensors for disposable bioreactor systems. / Steinwedel, Tobias; Dahlmann, Katharina; Solle, Dörte et al.
Single-Use Technology in Biopharmaceutical Manufacture. ed. / Regine Eibl; Dieter Eibl. 2. ed. Wiley-Blackwell, 2019. p. 69-82.

Research output: Chapter in book/report/conference proceedingContribution to book/anthologyResearchpeer review

Steinwedel, T, Dahlmann, K, Solle, D, Scheper, T, Reardon, KF & Lammers, F 2019, Sensors for disposable bioreactor systems. in R Eibl & D Eibl (eds), Single-Use Technology in Biopharmaceutical Manufacture. 2. edn, Wiley-Blackwell, pp. 69-82. https://doi.org/10.1002/9781119477891.ch6
Steinwedel, T., Dahlmann, K., Solle, D., Scheper, T., Reardon, K. F., & Lammers, F. (2019). Sensors for disposable bioreactor systems. In R. Eibl, & D. Eibl (Eds.), Single-Use Technology in Biopharmaceutical Manufacture (2. ed., pp. 69-82). Wiley-Blackwell. https://doi.org/10.1002/9781119477891.ch6
Steinwedel T, Dahlmann K, Solle D, Scheper T, Reardon KF, Lammers F. Sensors for disposable bioreactor systems. In Eibl R, Eibl D, editors, Single-Use Technology in Biopharmaceutical Manufacture. 2. ed. Wiley-Blackwell. 2019. p. 69-82 Epub 2019 Jul 26. doi: 10.1002/9781119477891.ch6
Steinwedel, Tobias ; Dahlmann, Katharina ; Solle, Dörte et al. / Sensors for disposable bioreactor systems. Single-Use Technology in Biopharmaceutical Manufacture. editor / Regine Eibl ; Dieter Eibl. 2. ed. Wiley-Blackwell, 2019. pp. 69-82
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