Details
| Original language | English |
|---|---|
| Pages (from-to) | 9605-9617 |
| Number of pages | 13 |
| Journal | The Journal of Physical Chemistry A |
| Volume | 126 |
| Issue number | 51 |
| Early online date | 16 Dec 2022 |
| Publication status | Published - 29 Dec 2022 |
Abstract
The growing interest in multifunctional nano-objects based on polymers and magnetic nanoparticles for biomedical applications motivated us to develop a scale-up protocol to increase the yield of polymeric magnetic nanobeads while aiming at keeping the structural features at optimal conditions. The protocol was applied to two different types of magnetic ferrite nanoparticles: the Mn-ferrite selected for their properties as contrast agents in magnetic resonance imaging and iron oxide nanostar shaped nanoparticles chosen for their heat performance in magnetic hyperthermia. At the same time, some experiments on surface functionalization of nanobeads with amino modified polyethyelene glycol (PEG) molecules have provided further insight into the formation mechanism of magnetic nanobeads and the need to cross-link the polymer shell to improve the stability of the beads, making them more suitable for further manipulation and use. The present work summarizes the most important parameters required to be controlled for the upscaling of nanobead synthesis in a bench protocol and proposes an alternative cross-linking strategy based on prefunctionalization of the polymer prior to the nanobead formation as a key parameter to improve the nanobead structural stability in solutions at different pHs and during surface functionalization.
ASJC Scopus subject areas
- Chemistry(all)
- Physical and Theoretical Chemistry
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In: The Journal of Physical Chemistry A, Vol. 126, No. 51, 29.12.2022, p. 9605-9617.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Scaling Up Magnetic Nanobead Synthesis with Improved Stability for Biomedical Applications
AU - Bigall, Nadja C.
AU - Rodio, Marina
AU - Avugadda, Sahitya
AU - Leal, Manuel Pernia
AU - Di Corato, Riccardo
AU - Conteh, John S.
AU - Intartaglia, Romuald
AU - Pellegrino, Teresa
N1 - Funding Information: N.C.B. is grateful for financial support from the German Federal Ministry of Education and Research (BMBF) within the framework of the program NanoMatFutur, support code 03 × 5525. T.P. acknowledges the AIRC Foundation (AIRC IG-14527) and the Marie SkłodowskaCurie Innovative training network MSCA-ITN-ETN (HeatNMof project, GA 860942).
PY - 2022/12/29
Y1 - 2022/12/29
N2 - The growing interest in multifunctional nano-objects based on polymers and magnetic nanoparticles for biomedical applications motivated us to develop a scale-up protocol to increase the yield of polymeric magnetic nanobeads while aiming at keeping the structural features at optimal conditions. The protocol was applied to two different types of magnetic ferrite nanoparticles: the Mn-ferrite selected for their properties as contrast agents in magnetic resonance imaging and iron oxide nanostar shaped nanoparticles chosen for their heat performance in magnetic hyperthermia. At the same time, some experiments on surface functionalization of nanobeads with amino modified polyethyelene glycol (PEG) molecules have provided further insight into the formation mechanism of magnetic nanobeads and the need to cross-link the polymer shell to improve the stability of the beads, making them more suitable for further manipulation and use. The present work summarizes the most important parameters required to be controlled for the upscaling of nanobead synthesis in a bench protocol and proposes an alternative cross-linking strategy based on prefunctionalization of the polymer prior to the nanobead formation as a key parameter to improve the nanobead structural stability in solutions at different pHs and during surface functionalization.
AB - The growing interest in multifunctional nano-objects based on polymers and magnetic nanoparticles for biomedical applications motivated us to develop a scale-up protocol to increase the yield of polymeric magnetic nanobeads while aiming at keeping the structural features at optimal conditions. The protocol was applied to two different types of magnetic ferrite nanoparticles: the Mn-ferrite selected for their properties as contrast agents in magnetic resonance imaging and iron oxide nanostar shaped nanoparticles chosen for their heat performance in magnetic hyperthermia. At the same time, some experiments on surface functionalization of nanobeads with amino modified polyethyelene glycol (PEG) molecules have provided further insight into the formation mechanism of magnetic nanobeads and the need to cross-link the polymer shell to improve the stability of the beads, making them more suitable for further manipulation and use. The present work summarizes the most important parameters required to be controlled for the upscaling of nanobead synthesis in a bench protocol and proposes an alternative cross-linking strategy based on prefunctionalization of the polymer prior to the nanobead formation as a key parameter to improve the nanobead structural stability in solutions at different pHs and during surface functionalization.
UR - http://www.scopus.com/inward/record.url?scp=85144233558&partnerID=8YFLogxK
U2 - 10.1021/acs.jpca.2c05902
DO - 10.1021/acs.jpca.2c05902
M3 - Article
C2 - 36524393
AN - SCOPUS:85144233558
VL - 126
SP - 9605
EP - 9617
JO - The Journal of Physical Chemistry A
JF - The Journal of Physical Chemistry A
SN - 1089-5639
IS - 51
ER -