Details
| Original language | German |
|---|---|
| Pages (from-to) | 4690-4708 |
| Journal | Chemical Reviews |
| Volume | 2010 |
| Issue number | 110 |
| Publication status | Published - 2010 |
Abstract
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In: Chemical Reviews, Vol. 2010, No. 110, 2010, p. 4690-4708.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Route to novel auxin: auxin chemical space toward biological correlation carriers.
AU - Reinard, Thomas
AU - Ferro, Noel
AU - Bredow, Thomas
PY - 2010
Y1 - 2010
N2 - The present state of knowledge on structure-activity relationships of auxin-like molecules and their biological repercussion based on different objectives was studied. Auxins act by modulation of multiple proteins rather than the dominant paradigm to act on individual targets. This necessitates characterizing the chemical moieties of auxin-like molecules more deeply by using tools of theoretical and combinatorial chemistry. The first relevant structural rules for auxins stated an auxin molecule requires a ring system as a nucleus, at least one double bond in the ring system, a side chain containing a carboxyl group with at least one atom removed from the ring, and a particular space relationship between the carboxyl group and the ring. It was studied that the action of an auxin consists in a physico-chemical influence of a boundary (PCIB). The existence of more than one receptor in the chain of auxin signal transduction demands the discrimination of the structural-binding relationships for each receptor-ligand pair and evaluation of the physiological relationships for each of them.
AB - The present state of knowledge on structure-activity relationships of auxin-like molecules and their biological repercussion based on different objectives was studied. Auxins act by modulation of multiple proteins rather than the dominant paradigm to act on individual targets. This necessitates characterizing the chemical moieties of auxin-like molecules more deeply by using tools of theoretical and combinatorial chemistry. The first relevant structural rules for auxins stated an auxin molecule requires a ring system as a nucleus, at least one double bond in the ring system, a side chain containing a carboxyl group with at least one atom removed from the ring, and a particular space relationship between the carboxyl group and the ring. It was studied that the action of an auxin consists in a physico-chemical influence of a boundary (PCIB). The existence of more than one receptor in the chain of auxin signal transduction demands the discrimination of the structural-binding relationships for each receptor-ligand pair and evaluation of the physiological relationships for each of them.
U2 - 10.1021/cr800229s
DO - 10.1021/cr800229s
M3 - Artikel
VL - 2010
SP - 4690
EP - 4708
JO - Chemical Reviews
JF - Chemical Reviews
SN - 0009-2665
IS - 110
ER -