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Role of miRNA let-7 and its major targets in prostate cancer

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Authors

External Research Organisations

  • Hannover Medical School (MHH)
  • University of Rostock
  • University of Veterinary Medicine of Hannover, Foundation

Details

Original languageEnglish
Pages (from-to)376326
JournalBioMed research international
Volume2014
Publication statusPublished - 2014

Abstract

Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate-specific antigen (PSA) is controversially discussed, as in many patients the prostate-specific antigen levels are chronically elevated in the absence of cancer. Due to the unsatisfying efficiency of available prostate cancer screening markers and the current treatment outcome of the aggressive hormone refractory prostate cancer, the evaluation of novel molecular markers and targets is considered an issue of high importance. MicroRNAs are relatively stable in body fluids orchestrating simultaneously the expression of many genes. These molecules are currently discussed to bear a greater diagnostic potential than protein-coding genes, being additionally promising therapeutic drugs and/or targets. Herein we review the potential impact of the microRNA let-7 family on prostate cancer and show how deregulation of several of its target genes could influence the cellular equilibrium in the prostate gland, promoting cancer development as they do in a variety of other human malignant neoplasias.

Keywords

    Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Humans, Male, MicroRNAs/genetics, Models, Biological, Prostatic Neoplasms/genetics

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Cite this

Role of miRNA let-7 and its major targets in prostate cancer. / Wagner, Siegfried; Ngezahayo, Anaclet; Murua Escobar, Hugo et al.
In: BioMed research international, Vol. 2014, 2014, p. 376326.

Research output: Contribution to journalReview articleResearchpeer review

Wagner S, Ngezahayo A, Murua Escobar H, Nolte I. Role of miRNA let-7 and its major targets in prostate cancer. BioMed research international. 2014;2014:376326. doi: 10.1155/2014/376326
Wagner, Siegfried ; Ngezahayo, Anaclet ; Murua Escobar, Hugo et al. / Role of miRNA let-7 and its major targets in prostate cancer. In: BioMed research international. 2014 ; Vol. 2014. pp. 376326.
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AU - Ngezahayo, Anaclet

AU - Murua Escobar, Hugo

AU - Nolte, Ingo

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KW - Genes, Neoplasm

KW - Humans

KW - Male

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KW - Models, Biological

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