Details
| Original language | English |
|---|---|
| Pages (from-to) | 260-263 |
| Number of pages | 4 |
| Journal | Environmental and Molecular Mutagenesis |
| Volume | 35 |
| Issue number | 3 |
| Publication status | Published - 6 Jun 2000 |
Abstract
A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of genotoxicity test procedures. Issues discussed included methods for integrating biological importance and statistical significance, the relationship of the experimental unit to the experimental design, and the impact of new developments in statistics and computing. Three major recommendations were made relating to the need for: (1) the effective use of statistical advice in designing interlaboratory and intralaboratory investigations; (2) the development of appropriate experimental designs for new assays; and (3) education and training in the use of statistical methodology in mutagenicity testing.
Keywords
- Experimental design, Genotoxicity, Statistics
ASJC Scopus subject areas
- Medicine(all)
- Epidemiology
- Medicine(all)
- Genetics(clinical)
- Environmental Science(all)
- Health, Toxicology and Mutagenesis
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In: Environmental and Molecular Mutagenesis, Vol. 35, No. 3, 06.06.2000, p. 260-263.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Report and summary of the major conclusions from statistics in genotoxicity testing working group from the International Workshop on Genotoxicity Test Procedures (IWGTP), March 1999
AU - Lovell, D. P.
AU - Yoshimura, I.
AU - Hothorn, L. A.
AU - Margolin, B. H.
AU - Soper Sandwich, S.
PY - 2000/6/6
Y1 - 2000/6/6
N2 - A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of genotoxicity test procedures. Issues discussed included methods for integrating biological importance and statistical significance, the relationship of the experimental unit to the experimental design, and the impact of new developments in statistics and computing. Three major recommendations were made relating to the need for: (1) the effective use of statistical advice in designing interlaboratory and intralaboratory investigations; (2) the development of appropriate experimental designs for new assays; and (3) education and training in the use of statistical methodology in mutagenicity testing.
AB - A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of genotoxicity test procedures. Issues discussed included methods for integrating biological importance and statistical significance, the relationship of the experimental unit to the experimental design, and the impact of new developments in statistics and computing. Three major recommendations were made relating to the need for: (1) the effective use of statistical advice in designing interlaboratory and intralaboratory investigations; (2) the development of appropriate experimental designs for new assays; and (3) education and training in the use of statistical methodology in mutagenicity testing.
KW - Experimental design
KW - Genotoxicity
KW - Statistics
UR - http://www.scopus.com/inward/record.url?scp=0034113930&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1098-2280(2000)35:3<260::AID-EM12>3.0.CO;2-O
DO - 10.1002/(SICI)1098-2280(2000)35:3<260::AID-EM12>3.0.CO;2-O
M3 - Article
C2 - 10737960
AN - SCOPUS:0034113930
VL - 35
SP - 260
EP - 263
JO - Environmental and Molecular Mutagenesis
JF - Environmental and Molecular Mutagenesis
SN - 0893-6692
IS - 3
ER -