Details
| Original language | English |
|---|---|
| Pages (from-to) | 695-699 |
| Number of pages | 5 |
| Journal | Applied Physics B: Lasers and Optics |
| Volume | 97 |
| Issue number | 3 |
| Publication status | Published - 3 Oct 2009 |
| Externally published | Yes |
Abstract
Femtosecond laser based nanosurgery of biological tissue is usually done in two different regimes. Depending on the application, low kHz repetition rates above the optical breakdown threshold or high MHz repetition rates in the low-density plasma regime are used. In contrast to the well understood optical breakdown, mechanisms leading to dissection below this threshold are not well known due to the complexity of chemical effects with high numbers of interacting molecules. Furthermore, the laser repetition rate may influence their efficiency. In this paper, we present our study on low-density plasma effects in biological tissue depending on repetition rate by static exposure of porcine corneal stroma to femtosecond pulses. We observed a continuous increase of the laser-induced damage with decreasing repetition rate over two orders of magnitude at constant numbers of applied laser pulses or constant laser pulse energies. Therefore, low repetition rates in the kHz regime are advantageous to minimize the total delivered energy to biological tissue during femtosecond laser irradiation. However, due to frequent excessive damage in this regime directly above the threshold, MHz repetition rates are preferable to create nanometer-sized cuts in the low-density plasma regime.
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Physics and Astronomy (miscellaneous)
- Physics and Astronomy(all)
- General Physics and Astronomy
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In: Applied Physics B: Lasers and Optics, Vol. 97, No. 3, 03.10.2009, p. 695-699.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Repetition rate dependency of low-density plasma effects during femtosecond-laser-based surgery of biological tissue
AU - Kuetemeyer, Kai
AU - Baumgart, Judith
AU - Lubatschowski, Holger
AU - Heisterkamp, Alexander
PY - 2009/10/3
Y1 - 2009/10/3
N2 - Femtosecond laser based nanosurgery of biological tissue is usually done in two different regimes. Depending on the application, low kHz repetition rates above the optical breakdown threshold or high MHz repetition rates in the low-density plasma regime are used. In contrast to the well understood optical breakdown, mechanisms leading to dissection below this threshold are not well known due to the complexity of chemical effects with high numbers of interacting molecules. Furthermore, the laser repetition rate may influence their efficiency. In this paper, we present our study on low-density plasma effects in biological tissue depending on repetition rate by static exposure of porcine corneal stroma to femtosecond pulses. We observed a continuous increase of the laser-induced damage with decreasing repetition rate over two orders of magnitude at constant numbers of applied laser pulses or constant laser pulse energies. Therefore, low repetition rates in the kHz regime are advantageous to minimize the total delivered energy to biological tissue during femtosecond laser irradiation. However, due to frequent excessive damage in this regime directly above the threshold, MHz repetition rates are preferable to create nanometer-sized cuts in the low-density plasma regime.
AB - Femtosecond laser based nanosurgery of biological tissue is usually done in two different regimes. Depending on the application, low kHz repetition rates above the optical breakdown threshold or high MHz repetition rates in the low-density plasma regime are used. In contrast to the well understood optical breakdown, mechanisms leading to dissection below this threshold are not well known due to the complexity of chemical effects with high numbers of interacting molecules. Furthermore, the laser repetition rate may influence their efficiency. In this paper, we present our study on low-density plasma effects in biological tissue depending on repetition rate by static exposure of porcine corneal stroma to femtosecond pulses. We observed a continuous increase of the laser-induced damage with decreasing repetition rate over two orders of magnitude at constant numbers of applied laser pulses or constant laser pulse energies. Therefore, low repetition rates in the kHz regime are advantageous to minimize the total delivered energy to biological tissue during femtosecond laser irradiation. However, due to frequent excessive damage in this regime directly above the threshold, MHz repetition rates are preferable to create nanometer-sized cuts in the low-density plasma regime.
UR - http://www.scopus.com/inward/record.url?scp=70350567217&partnerID=8YFLogxK
U2 - 10.1007/s00340-009-3746-y
DO - 10.1007/s00340-009-3746-y
M3 - Article
AN - SCOPUS:70350567217
VL - 97
SP - 695
EP - 699
JO - Applied Physics B: Lasers and Optics
JF - Applied Physics B: Lasers and Optics
SN - 0946-2171
IS - 3
ER -