Remarkable hydrolysis of phosphodiester by neutral lanthanide(III) DO3A complexes

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Original languageEnglish
Pages (from-to)2063-2068
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number17
Publication statusPublished - 3 Sept 1996

Abstract

The hydrolysis of the 4-nitrophenyl phosphate ester of propylene glycol (HPNP) is catalyzed by neutral lanthanide(III) DO3A complexes. Hydrolysis experiments with complexes of modified ligands where the metal complex was positively charged did not yield in a significant increase of the rate constant.

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Remarkable hydrolysis of phosphodiester by neutral lanthanide(III) DO3A complexes. / Kalesse, Markus; Loos, Andrea.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 17, 03.09.1996, p. 2063-2068.

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abstract = "The hydrolysis of the 4-nitrophenyl phosphate ester of propylene glycol (HPNP) is catalyzed by neutral lanthanide(III) DO3A complexes. Hydrolysis experiments with complexes of modified ligands where the metal complex was positively charged did not yield in a significant increase of the rate constant.",
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AU - Loos, Andrea

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