Details
| Original language | English |
|---|---|
| Pages (from-to) | 53-57 |
| Number of pages | 5 |
| Journal | BioNanoMaterials |
| Volume | 17 |
| Issue number | 1-2 |
| Publication status | Published - 12 Apr 2016 |
| Externally published | Yes |
Abstract
Implant-associated infections still pose serious problems in modern medicine. The development of fabrication processes to generate functional surfaces, which inhibit bacterial attachment, is of major importance. Sharklet™-like as well as grooves and grid micro-structures having similar dimensions were fabricated on the common implant material titanium by ultra-short pulsed laser ablation. Investigations on the biofilm formation of Staphylococcus aureus for up to 24 h revealed similarly reduced bacterial surface coverage on all micro-structures investigated compared to smooth titanium surfaces. This study is a prove-of-principle and could serve as basis for further investigations towards a structure-based biofilm-inhibiting implant.
Keywords
- implant-associated infection, micro-structured surface, reduced bacterial adhesion, Sharklet™ surface, ultra-short pulsed laser ablation
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Engineering(all)
- Biomedical Engineering
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In: BioNanoMaterials, Vol. 17, No. 1-2, 12.04.2016, p. 53-57.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Reduced bacterial adhesion on titanium surfaces micro-structured by ultra-short pulsed laser ablation
AU - Doll, Katharina
AU - Fadeeva, Elena
AU - Stumpp, Nico S.
AU - Grade, Sebastian
AU - Chichkov, Boris N.
AU - Stiesch, Meike
N1 - Funding information: This work has been carried out as an integral part of the BIOFABRICATION FOR NIFE initiative, which is financially supported by the ministry of Lower Saxony and the Volkswagen Foundation.
PY - 2016/4/12
Y1 - 2016/4/12
N2 - Implant-associated infections still pose serious problems in modern medicine. The development of fabrication processes to generate functional surfaces, which inhibit bacterial attachment, is of major importance. Sharklet™-like as well as grooves and grid micro-structures having similar dimensions were fabricated on the common implant material titanium by ultra-short pulsed laser ablation. Investigations on the biofilm formation of Staphylococcus aureus for up to 24 h revealed similarly reduced bacterial surface coverage on all micro-structures investigated compared to smooth titanium surfaces. This study is a prove-of-principle and could serve as basis for further investigations towards a structure-based biofilm-inhibiting implant.
AB - Implant-associated infections still pose serious problems in modern medicine. The development of fabrication processes to generate functional surfaces, which inhibit bacterial attachment, is of major importance. Sharklet™-like as well as grooves and grid micro-structures having similar dimensions were fabricated on the common implant material titanium by ultra-short pulsed laser ablation. Investigations on the biofilm formation of Staphylococcus aureus for up to 24 h revealed similarly reduced bacterial surface coverage on all micro-structures investigated compared to smooth titanium surfaces. This study is a prove-of-principle and could serve as basis for further investigations towards a structure-based biofilm-inhibiting implant.
KW - implant-associated infection
KW - micro-structured surface
KW - reduced bacterial adhesion
KW - Sharklet™ surface
KW - ultra-short pulsed laser ablation
UR - http://www.scopus.com/inward/record.url?scp=84991518471&partnerID=8YFLogxK
U2 - 10.1515/bnm-2015-0024
DO - 10.1515/bnm-2015-0024
M3 - Article
AN - SCOPUS:84991518471
VL - 17
SP - 53
EP - 57
JO - BioNanoMaterials
JF - BioNanoMaterials
SN - 2193-0651
IS - 1-2
ER -