Details
| Original language | English |
|---|---|
| Pages (from-to) | 318-341 |
| Number of pages | 24 |
| Journal | Natural Product Reports |
| Volume | 25 |
| Issue number | 2 |
| Publication status | Published - 2008 |
Abstract
A detailed overview is presented of recent total synthesis approaches to four different diterpenoids - the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemistry. Additionally, all four diterpenoids are of major relevance because of their biological (target) or pharmaceutical properties.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural Product Reports, Vol. 25, No. 2, 2008, p. 318-341.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Recent advances in the total synthesis of pharmaceutically relevant diterpenes
AU - Busch, Torsten
AU - Kirschning, Andreas
PY - 2008
Y1 - 2008
N2 - A detailed overview is presented of recent total synthesis approaches to four different diterpenoids - the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemistry. Additionally, all four diterpenoids are of major relevance because of their biological (target) or pharmaceutical properties.
AB - A detailed overview is presented of recent total synthesis approaches to four different diterpenoids - the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemistry. Additionally, all four diterpenoids are of major relevance because of their biological (target) or pharmaceutical properties.
UR - http://www.scopus.com/inward/record.url?scp=41849127508&partnerID=8YFLogxK
U2 - 10.1039/b705652b
DO - 10.1039/b705652b
M3 - Review article
C2 - 18389140
AN - SCOPUS:41849127508
VL - 25
SP - 318
EP - 341
JO - Natural Product Reports
JF - Natural Product Reports
SN - 0265-0568
IS - 2
ER -