Details
| Original language | English |
|---|---|
| Pages (from-to) | 193-201 |
| Number of pages | 9 |
| Journal | Nature nanotechnology |
| Volume | 4 |
| Issue number | 3 |
| Publication status | Published - Mar 2009 |
| Externally published | Yes |
Abstract
Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins - micelles that transport lipids and other hydrophobic substances in the blood - and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Engineering(all)
- Biomedical Engineering
- Materials Science(all)
- General Materials Science
- Physics and Astronomy(all)
- Condensed Matter Physics
- Engineering(all)
- Electrical and Electronic Engineering
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In: Nature nanotechnology, Vol. 4, No. 3, 03.2009, p. 193-201.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals
AU - Bruns, Oliver T.
AU - Ittrich, Harald
AU - Peldschus, Kersten
AU - Kaul, Michael G.
AU - Tromsdorf, Ulrich I.
AU - Lauterwasser, Joachim
AU - Nikolic, Marija S.
AU - Mollwitz, Birgit
AU - Merkel, Martin
AU - Bigall, Nadja C.
AU - Sapra, Sameer
AU - Reimer, Rudolph
AU - Hohenberg, Heinz
AU - Weller, Horst
AU - Eychmüller, Alexander
AU - Adam, Gerhard
AU - Beisiegel, Ulrike
AU - Heeren, Joerg
N1 - Funding information: The authors thank A. Laatsch, R. Fischer and A. Bartelt for helpful discussions. K. Cornils, B. Holstermann, M. Warmer, S. Ehret and R. Kongi for excellent technical assistance, A. Kornowski for electron microscopy images and R. Capek for providing QD. O.T.B. is supported by a fellowship from the Studienstiftung des Deutschen Volkes. This work was supported by grants from the Deutsche Forschungsgemeinschaft to J.H., U.B. and A.E. (HE3645/2-2, BE829/10-1 and EY16/9-1).
PY - 2009/3
Y1 - 2009/3
N2 - Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins - micelles that transport lipids and other hydrophobic substances in the blood - and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.
AB - Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins - micelles that transport lipids and other hydrophobic substances in the blood - and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.
UR - http://www.scopus.com/inward/record.url?scp=62249165791&partnerID=8YFLogxK
U2 - 10.1038/nnano.2008.405
DO - 10.1038/nnano.2008.405
M3 - Article
C2 - 19265850
AN - SCOPUS:62249165791
VL - 4
SP - 193
EP - 201
JO - Nature nanotechnology
JF - Nature nanotechnology
SN - 1748-3387
IS - 3
ER -