Details
| Original language | English |
|---|---|
| Pages (from-to) | 369-371 |
| Number of pages | 3 |
| Journal | CHEMBIOCHEM |
| Volume | 5 |
| Issue number | 3 |
| Publication status | Published - 5 Mar 2004 |
Abstract
Adding more sugar: Overexpression of the landomycin glycosyltransferase gene lanGT4 in Streptomyces fradiae Tü2717 resulted in the conversion of the urdamycin trisaccharide into an unnatural tetrasaccharide by transfer of an L-rhodinose unit. We propose that LanGT4 is able to act iteratively on growing saccharide chains.
Keywords
- Biosynthesis, Drug design, Enzymes, Glycosyltransferase, Urdamycin
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Medicine
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Chemistry(all)
- Organic Chemistry
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In: CHEMBIOCHEM, Vol. 5, No. 3, 05.03.2004, p. 369-371.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Rational saccharide extension by using the natural product glycosyltransferase LanGT4
AU - Hoffmeister, Dirk
AU - Weber, Monika
AU - Dräger, Gerald
AU - Ichinose, Koji
AU - Dürr, Clemens
AU - Bechthold, Andreas
N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/3/5
Y1 - 2004/3/5
N2 - Adding more sugar: Overexpression of the landomycin glycosyltransferase gene lanGT4 in Streptomyces fradiae Tü2717 resulted in the conversion of the urdamycin trisaccharide into an unnatural tetrasaccharide by transfer of an L-rhodinose unit. We propose that LanGT4 is able to act iteratively on growing saccharide chains.
AB - Adding more sugar: Overexpression of the landomycin glycosyltransferase gene lanGT4 in Streptomyces fradiae Tü2717 resulted in the conversion of the urdamycin trisaccharide into an unnatural tetrasaccharide by transfer of an L-rhodinose unit. We propose that LanGT4 is able to act iteratively on growing saccharide chains.
KW - Biosynthesis
KW - Drug design
KW - Enzymes
KW - Glycosyltransferase
KW - Urdamycin
UR - http://www.scopus.com/inward/record.url?scp=4544369703&partnerID=8YFLogxK
U2 - 10.1002/cbic.200300793
DO - 10.1002/cbic.200300793
M3 - Article
C2 - 14997529
AN - SCOPUS:4544369703
VL - 5
SP - 369
EP - 371
JO - CHEMBIOCHEM
JF - CHEMBIOCHEM
SN - 1439-4227
IS - 3
ER -