Raspberry ketone from submerged cultured cells of the basidiomycete Nidula niveo-tomentosa

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Authors

  • Andreas Böker
  • R. G. Berger
  • Manuela Fischer

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Details

Original languageEnglish
Pages (from-to)568-572
Number of pages5
JournalBiotechnology progress
Volume17
Issue number3
Publication statusPublished - 2001

Abstract

The basidiomycete Nidula niveo-tomentosa produced 4-(4-hydroxyphenyl)-butan-2-one (raspberry ketone), one of the character impact components of raspberry flavor, and its corresponding alcohol. A systematic attempt was made to improve the productivity of this fungus. Variation of nutrient medium composition, precursor amount, time of supplementation, and cultivation period yielded a 50-fold increase in metabolite concentrations. Raspberry ketone and alcohol were easily isolated from the culture medium by solvent extraction. Glycosidically bound forms or accumulation of raspberry compounds in fungal cells were not detected. This microbial process offers an alternative for the production of natural raspberry flavor.

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Raspberry ketone from submerged cultured cells of the basidiomycete Nidula niveo-tomentosa. / Böker, Andreas; Berger, R. G.; Fischer, Manuela.
In: Biotechnology progress, Vol. 17, No. 3, 2001, p. 568-572.

Research output: Contribution to journalArticleResearchpeer review

Böker A, Berger RG, Fischer M. Raspberry ketone from submerged cultured cells of the basidiomycete Nidula niveo-tomentosa. Biotechnology progress. 2001;17(3):568-572. doi: 10.1021/bp010011b
Böker, Andreas ; Berger, R. G. ; Fischer, Manuela. / Raspberry ketone from submerged cultured cells of the basidiomycete Nidula niveo-tomentosa. In: Biotechnology progress. 2001 ; Vol. 17, No. 3. pp. 568-572.
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