Details
| Original language | English |
|---|---|
| Pages (from-to) | 622-626 |
| Number of pages | 5 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 344 |
| Issue number | 6-7 |
| Publication status | Published - 20 Aug 2002 |
| Externally published | Yes |
Abstract
A new strategy for the synthesis of a well-defined glycolipid library is presented. A highly selective cross metathesis reaction is used to diversify the lipid moiety of anomerically pure α- or β-glycosides, and subsequent functionalization of the double bond allows further expansion of the diversity. These glycolipids are being investigated for their effect on the immune system, especially the CD1-mediated T-cell activation.
Keywords
- Cross metathesis, Glycolipid library, Parallel synthesis
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Organic Chemistry
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In: Advanced Synthesis and Catalysis, Vol. 344, No. 6-7, 20.08.2002, p. 622-626.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Rapid preparation of glycolipid libraries by cross metathesis
AU - Plettenburg, Oliver
AU - Mui, Cosina
AU - Bodmer-Narkevitch, Vera
AU - Wong, Chi Huey
PY - 2002/8/20
Y1 - 2002/8/20
N2 - A new strategy for the synthesis of a well-defined glycolipid library is presented. A highly selective cross metathesis reaction is used to diversify the lipid moiety of anomerically pure α- or β-glycosides, and subsequent functionalization of the double bond allows further expansion of the diversity. These glycolipids are being investigated for their effect on the immune system, especially the CD1-mediated T-cell activation.
AB - A new strategy for the synthesis of a well-defined glycolipid library is presented. A highly selective cross metathesis reaction is used to diversify the lipid moiety of anomerically pure α- or β-glycosides, and subsequent functionalization of the double bond allows further expansion of the diversity. These glycolipids are being investigated for their effect on the immune system, especially the CD1-mediated T-cell activation.
KW - Cross metathesis
KW - Glycolipid library
KW - Parallel synthesis
UR - http://www.scopus.com/inward/record.url?scp=0141469359&partnerID=8YFLogxK
U2 - 10.1002/1615-4169(200208)344:6/7<622::AID-ADSC622>3.0.CO;2-W
DO - 10.1002/1615-4169(200208)344:6/7<622::AID-ADSC622>3.0.CO;2-W
M3 - Article
AN - SCOPUS:0141469359
VL - 344
SP - 622
EP - 626
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
SN - 1615-4150
IS - 6-7
ER -