Details
| Original language | English |
|---|---|
| Pages (from-to) | 13463-13467 |
| Number of pages | 5 |
| Journal | Chemical science |
| Volume | 14 |
| Issue number | 46 |
| Publication status | Published - 8 Nov 2023 |
Abstract
Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism Aspergillus oryzae. Compounds produced in a single step include the natural product hypoxylan A and an epimer of guignaderemophilane C. A new fungal aromatase was discovered that produces phenols by oxidative demethylation.
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Chemical science, Vol. 14, No. 46, 08.11.2023, p. 13463-13467.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Rapid discovery of terpene tailoring enzymes for total biosynthesis
AU - Sun, Yunlong
AU - Gerke, Jennifer
AU - Becker, Kevin
AU - Kuhnert, Eric
AU - Verwaaijen, Bart
AU - Wibberg, Daniel
AU - Kalinowski, Jörn
AU - Stadler, Marc
AU - Cox, Russell J.
N1 - Funding Information: YS thanks the China Scholarship Council for a scholarship (201908360165). This work was funded by the Deutsche Forschungsgemeinschaft priority program “Taxon-Omics: New Approaches for Discovering and Naming Biodiversity” (SPP 1991), specifically CO 1328/4-2 and CO 1328/4-1. The bioinformatics support of the BMBF-funded project ‘Bielefeld-Gießen Center for Microbial Bioinformatics; BiGi (Grant number 031A533)’ within the German Network for Bioinformatics Infrastructure (de.NBI) is gratefully acknowledged.
PY - 2023/11/8
Y1 - 2023/11/8
N2 - Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism Aspergillus oryzae. Compounds produced in a single step include the natural product hypoxylan A and an epimer of guignaderemophilane C. A new fungal aromatase was discovered that produces phenols by oxidative demethylation.
AB - Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism Aspergillus oryzae. Compounds produced in a single step include the natural product hypoxylan A and an epimer of guignaderemophilane C. A new fungal aromatase was discovered that produces phenols by oxidative demethylation.
UR - http://www.scopus.com/inward/record.url?scp=85176813932&partnerID=8YFLogxK
U2 - 10.1039/d3sc04172g
DO - 10.1039/d3sc04172g
M3 - Article
AN - SCOPUS:85176813932
VL - 14
SP - 13463
EP - 13467
JO - Chemical science
JF - Chemical science
SN - 2041-6520
IS - 46
ER -