Details
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Pages | 601-602 |
| Number of pages | 2 |
| ISBN (electronic) | 9781733419017 |
| Publication status | Published - 2020 |
| Event | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online Duration: 4 Oct 2020 → 9 Oct 2020 |
Publication series
| Name | MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Abstract
In this work, we present a sensing system for rapid antifungal susceptibility testing (AFST). The sensor is based on silicon-based diffraction gratings; their microstructure allows to capture the fungal conidia and monitor their subsequent growth on a solid-liquid interface. As a proof of concept, we use Aspergillus Niger (A. Niger) and study its growth and response to common antifungals (at varying concentrations) by monitoring changes in the intensity of reflected light from the grating. The assay is employed for the determination of minimum inhibitory concentration (MIC) values and allows expeditious AFST within 12 h, compared to ~1-2 days using gold standard methods.
Keywords
- Antifungal Susceptibility Testing, Sensors, Silicon Microwell Diffraction Gratings
ASJC Scopus subject areas
- Chemical Engineering(all)
- Chemical Engineering (miscellaneous)
- Chemical Engineering(all)
- Bioengineering
- Chemistry(all)
- Engineering(all)
- Control and Systems Engineering
Cite this
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MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2020. p. 601-602 (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Rapid antifungal susceptibility testing on silicon microwells
AU - Heuer, Christopher
AU - Leonard, Heidi
AU - Nitzan, Nadav
AU - Lavy-Alperovitch, Ariella
AU - Massad-Ivanir, Naama
AU - Bahnemann, Janina
AU - Scheper, Thomas
AU - Segal, Ester
N1 - Funding information: This work was partially supported by the Israel Innovation Authority. CH acknowledges the financial support from the Leibniz Universitätsgesellschaft and the Technion. This work was partially supported by the Israel Innovation Authority. CH acknowledges the financial support from the Leibniz Universit?tsgesellschaft and the Technion.
PY - 2020
Y1 - 2020
N2 - In this work, we present a sensing system for rapid antifungal susceptibility testing (AFST). The sensor is based on silicon-based diffraction gratings; their microstructure allows to capture the fungal conidia and monitor their subsequent growth on a solid-liquid interface. As a proof of concept, we use Aspergillus Niger (A. Niger) and study its growth and response to common antifungals (at varying concentrations) by monitoring changes in the intensity of reflected light from the grating. The assay is employed for the determination of minimum inhibitory concentration (MIC) values and allows expeditious AFST within 12 h, compared to ~1-2 days using gold standard methods.
AB - In this work, we present a sensing system for rapid antifungal susceptibility testing (AFST). The sensor is based on silicon-based diffraction gratings; their microstructure allows to capture the fungal conidia and monitor their subsequent growth on a solid-liquid interface. As a proof of concept, we use Aspergillus Niger (A. Niger) and study its growth and response to common antifungals (at varying concentrations) by monitoring changes in the intensity of reflected light from the grating. The assay is employed for the determination of minimum inhibitory concentration (MIC) values and allows expeditious AFST within 12 h, compared to ~1-2 days using gold standard methods.
KW - Antifungal Susceptibility Testing
KW - Sensors
KW - Silicon Microwell Diffraction Gratings
UR - http://www.scopus.com/inward/record.url?scp=85098262497&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85098262497
T3 - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 601
EP - 602
BT - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
Y2 - 4 October 2020 through 9 October 2020
ER -