Details
| Original language | English |
|---|---|
| Pages (from-to) | 17-22 |
| Number of pages | 6 |
| Journal | International Journal for Ion Mobility Spectrometry |
| Volume | 18 |
| Issue number | 1 |
| Publication status | Published - 21 Feb 2015 |
Abstract
Recently, we have published an analytical model describing the resolution and signal-to-noise-ratio of peaks present in an ion mobility spectrum acquired by a drift tube instrument. Based on this model, we designed a combination of a compact 10 cm long drift tube and a fast transimpedance amplifier achieving a resolution above 180. Here, we present results using an improved drift tube with slightly longer drift length of 15 cm and higher drift voltages, resulting in a resolution of R = 250 for the positive reactant ion peak and R = 230 for the negative reactant ion peak. By applying a deconvolution algorithm based on the Jansson method, a two- to three-fold separation improvement is possible in theory. However, as a larger resolution improvement than the initial resolution loss by diffusion may lead to erroneous results, we limited the resolution enhancement to 70 %, reaching a resolution of R = 425 for deconvolved spectra.
Keywords
- Deconvolution, Drift tube, Ion mobility spectrometry, Jansson method, Ultra-high resolution
ASJC Scopus subject areas
- Chemistry(all)
- Spectroscopy
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In: International Journal for Ion Mobility Spectrometry, Vol. 18, No. 1, 21.02.2015, p. 17-22.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Pushing a compact 15 cm long ultra-high resolution drift tube ion mobility spectrometer with R = 250 to R = 425 using peak deconvolution
AU - Kirk, Ansgar T.
AU - Zimmermann, Stefan
PY - 2015/2/21
Y1 - 2015/2/21
N2 - Recently, we have published an analytical model describing the resolution and signal-to-noise-ratio of peaks present in an ion mobility spectrum acquired by a drift tube instrument. Based on this model, we designed a combination of a compact 10 cm long drift tube and a fast transimpedance amplifier achieving a resolution above 180. Here, we present results using an improved drift tube with slightly longer drift length of 15 cm and higher drift voltages, resulting in a resolution of R = 250 for the positive reactant ion peak and R = 230 for the negative reactant ion peak. By applying a deconvolution algorithm based on the Jansson method, a two- to three-fold separation improvement is possible in theory. However, as a larger resolution improvement than the initial resolution loss by diffusion may lead to erroneous results, we limited the resolution enhancement to 70 %, reaching a resolution of R = 425 for deconvolved spectra.
AB - Recently, we have published an analytical model describing the resolution and signal-to-noise-ratio of peaks present in an ion mobility spectrum acquired by a drift tube instrument. Based on this model, we designed a combination of a compact 10 cm long drift tube and a fast transimpedance amplifier achieving a resolution above 180. Here, we present results using an improved drift tube with slightly longer drift length of 15 cm and higher drift voltages, resulting in a resolution of R = 250 for the positive reactant ion peak and R = 230 for the negative reactant ion peak. By applying a deconvolution algorithm based on the Jansson method, a two- to three-fold separation improvement is possible in theory. However, as a larger resolution improvement than the initial resolution loss by diffusion may lead to erroneous results, we limited the resolution enhancement to 70 %, reaching a resolution of R = 425 for deconvolved spectra.
KW - Deconvolution
KW - Drift tube
KW - Ion mobility spectrometry
KW - Jansson method
KW - Ultra-high resolution
UR - http://www.scopus.com/inward/record.url?scp=84929835743&partnerID=8YFLogxK
U2 - 10.15488/4407
DO - 10.15488/4407
M3 - Article
AN - SCOPUS:84929835743
VL - 18
SP - 17
EP - 22
JO - International Journal for Ion Mobility Spectrometry
JF - International Journal for Ion Mobility Spectrometry
SN - 1435-6163
IS - 1
ER -