Details
| Original language | English |
|---|---|
| Pages (from-to) | 214-223 |
| Number of pages | 10 |
| Journal | Journal of biomedical optics |
| Volume | 6 |
| Issue number | 2 |
| Publication status | Published - 1 Apr 2001 |
Abstract
Pulsed photothermal radiometry (PPTR) is known to be suitable for in vivo investigations of tissue optical properties. As a noncontact, nondestructive method it is a very attractive candidate for on-line dosimetry of laser treatments that rely on thermal laser-tissue interaction. In this article, we extend the one-dimensional (1D) analytical formalism that has widely been used to describe PPTR signals to a two-dimensional treatment of a simplified model of a blood vessel. This approach leads to quantitative description of a PPTR signal that, unlike in an 1D treatment, not only shows changes in time, but also varies in space. Using this approach, we are able to gain instructive understanding on how target characteristics of a blood vessel-like structure influence such a spatiotemporal PPTR signal. Likewise, the ability of extracting target features from those measurements is evaluated. Subsequently, we present experimental realization of the idealized model of a blood vessel as used in our theory. Comparison of actual PPTR measurements with theoretical predictions allow vessel localization laterally and in depth. Using our setup, we furthermore demonstrate the influence of flow inside the vessel on the measured signal.
Keywords
- Blood flow, Blood vessels, On-line-dosimetry, Pulsed photothermal radiometry, Thermal imaging, Tissue optics
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Materials Science(all)
- Biomaterials
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Engineering(all)
- Biomedical Engineering
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In: Journal of biomedical optics, Vol. 6, No. 2, 01.04.2001, p. 214-223.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Pulsed photothermal radiometry as a method for investigating blood vessel-like structures
AU - Schmitz, C. H.
AU - Oberheide, U.
AU - Lohmann, S.
AU - Lubatschowski, H.
AU - Ertmer, W.
PY - 2001/4/1
Y1 - 2001/4/1
N2 - Pulsed photothermal radiometry (PPTR) is known to be suitable for in vivo investigations of tissue optical properties. As a noncontact, nondestructive method it is a very attractive candidate for on-line dosimetry of laser treatments that rely on thermal laser-tissue interaction. In this article, we extend the one-dimensional (1D) analytical formalism that has widely been used to describe PPTR signals to a two-dimensional treatment of a simplified model of a blood vessel. This approach leads to quantitative description of a PPTR signal that, unlike in an 1D treatment, not only shows changes in time, but also varies in space. Using this approach, we are able to gain instructive understanding on how target characteristics of a blood vessel-like structure influence such a spatiotemporal PPTR signal. Likewise, the ability of extracting target features from those measurements is evaluated. Subsequently, we present experimental realization of the idealized model of a blood vessel as used in our theory. Comparison of actual PPTR measurements with theoretical predictions allow vessel localization laterally and in depth. Using our setup, we furthermore demonstrate the influence of flow inside the vessel on the measured signal.
AB - Pulsed photothermal radiometry (PPTR) is known to be suitable for in vivo investigations of tissue optical properties. As a noncontact, nondestructive method it is a very attractive candidate for on-line dosimetry of laser treatments that rely on thermal laser-tissue interaction. In this article, we extend the one-dimensional (1D) analytical formalism that has widely been used to describe PPTR signals to a two-dimensional treatment of a simplified model of a blood vessel. This approach leads to quantitative description of a PPTR signal that, unlike in an 1D treatment, not only shows changes in time, but also varies in space. Using this approach, we are able to gain instructive understanding on how target characteristics of a blood vessel-like structure influence such a spatiotemporal PPTR signal. Likewise, the ability of extracting target features from those measurements is evaluated. Subsequently, we present experimental realization of the idealized model of a blood vessel as used in our theory. Comparison of actual PPTR measurements with theoretical predictions allow vessel localization laterally and in depth. Using our setup, we furthermore demonstrate the influence of flow inside the vessel on the measured signal.
KW - Blood flow
KW - Blood vessels
KW - On-line-dosimetry
KW - Pulsed photothermal radiometry
KW - Thermal imaging
KW - Tissue optics
UR - http://www.scopus.com/inward/record.url?scp=0035297595&partnerID=8YFLogxK
U2 - 10.1117/1.1344193
DO - 10.1117/1.1344193
M3 - Article
C2 - 11375732
AN - SCOPUS:0035297595
VL - 6
SP - 214
EP - 223
JO - Journal of biomedical optics
JF - Journal of biomedical optics
SN - 1083-3668
IS - 2
ER -