Details
| Original language | English |
|---|---|
| Pages (from-to) | 3585-3589 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 582 |
| Issue number | 25-26 |
| Publication status | Published - 29 Oct 2008 |
| Externally published | Yes |
Abstract
The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30-40 nm diameter with a scaffold-like arrangement of protein subunits at the surface. The 'PspA-scaffold' is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.
Keywords
- Membrane stabilization, Membrane stress, Phage shock protein
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biophysics
- Biochemistry, Genetics and Molecular Biology(all)
- Structural Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Genetics
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
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In: FEBS Letters, Vol. 582, No. 25-26, 29.10.2008, p. 3585-3589.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - PspA can form large scaffolds in Escherichia coli
AU - Standar, Kerstin
AU - Mehner, Denise
AU - Osadnik, Hendrik
AU - Berthelmann, Felix
AU - Hause, Gerd
AU - Lünsdorf, Heinrich
AU - Brüser, Thomas
N1 - Funding Information: We are grateful to Jan R. Andreesen and Gary Sawers for discussions and support. This work was supported by the Deutsche Forschungsgemeinschaft with Grant BR2285/2-2 to T.B. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/10/29
Y1 - 2008/10/29
N2 - The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30-40 nm diameter with a scaffold-like arrangement of protein subunits at the surface. The 'PspA-scaffold' is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.
AB - The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30-40 nm diameter with a scaffold-like arrangement of protein subunits at the surface. The 'PspA-scaffold' is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.
KW - Membrane stabilization
KW - Membrane stress
KW - Phage shock protein
UR - http://www.scopus.com/inward/record.url?scp=53949112044&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2008.09.002
DO - 10.1016/j.febslet.2008.09.002
M3 - Article
C2 - 18789328
AN - SCOPUS:53949112044
VL - 582
SP - 3585
EP - 3589
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 25-26
ER -