Details
| Original language | English |
|---|---|
| Pages (from-to) | 175-193 |
| Number of pages | 19 |
| Journal | Journal of biotechnology |
| Volume | 54 |
| Issue number | 3 |
| Publication status | Published - 9 May 1997 |
Abstract
The goal of bioprocess-control and-scheduling is to maximize the profit of the whole process. Maximizing of the profit implies the optimal coordination among the subindices such as productivity, yield and quality of the product. These three subindices often interact with each other since the manipulating variables may influence them simultaneously. Therefore, the best way to control the process is to optimize the profit index directly. In this paper, it is illustrated by an example of industrial penicillin fed-batch production how the profit index, named as profit function, is established. Tile profit function is an objective description of a process under the aspect of economy. In reality, it may be found that the profit function is often different from batch to batch. Such a fluctuation is demonstrated by gibberellic acid, penicillin and cephalosporin fed-batch processes. This suggests that optimal scheduling of process time may be an effective way to enhance the total profit. Based on a database which consists of the characteristic description of the profit function of earlier batches, tile procedures of classification and optimal scheduling decision are described in details. On-line profit optimization may be done in particular if a process model is available. This is demonstrated with cephalosporin C fed-batch cultivation as an example.
Keywords
- Adaptive model, Cephalosporin, Gibberellic acid, Optimal scheduling, Penicillin, Profit function
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
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In: Journal of biotechnology, Vol. 54, No. 3, 09.05.1997, p. 175-193.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Profit optimization for mycelia fed-batch cultivation
AU - Yuan, J. Q.
AU - Guo, S. R.
AU - Schügerl, K.
AU - Bellgardt, K. H.
N1 - Funding Information: This work was carried out in the Institute of Chemical Engineering of University Hannover. J.Q. Yuan would like to acknowledge the financial support of the Alexander von Humboldt Foundation.
PY - 1997/5/9
Y1 - 1997/5/9
N2 - The goal of bioprocess-control and-scheduling is to maximize the profit of the whole process. Maximizing of the profit implies the optimal coordination among the subindices such as productivity, yield and quality of the product. These three subindices often interact with each other since the manipulating variables may influence them simultaneously. Therefore, the best way to control the process is to optimize the profit index directly. In this paper, it is illustrated by an example of industrial penicillin fed-batch production how the profit index, named as profit function, is established. Tile profit function is an objective description of a process under the aspect of economy. In reality, it may be found that the profit function is often different from batch to batch. Such a fluctuation is demonstrated by gibberellic acid, penicillin and cephalosporin fed-batch processes. This suggests that optimal scheduling of process time may be an effective way to enhance the total profit. Based on a database which consists of the characteristic description of the profit function of earlier batches, tile procedures of classification and optimal scheduling decision are described in details. On-line profit optimization may be done in particular if a process model is available. This is demonstrated with cephalosporin C fed-batch cultivation as an example.
AB - The goal of bioprocess-control and-scheduling is to maximize the profit of the whole process. Maximizing of the profit implies the optimal coordination among the subindices such as productivity, yield and quality of the product. These three subindices often interact with each other since the manipulating variables may influence them simultaneously. Therefore, the best way to control the process is to optimize the profit index directly. In this paper, it is illustrated by an example of industrial penicillin fed-batch production how the profit index, named as profit function, is established. Tile profit function is an objective description of a process under the aspect of economy. In reality, it may be found that the profit function is often different from batch to batch. Such a fluctuation is demonstrated by gibberellic acid, penicillin and cephalosporin fed-batch processes. This suggests that optimal scheduling of process time may be an effective way to enhance the total profit. Based on a database which consists of the characteristic description of the profit function of earlier batches, tile procedures of classification and optimal scheduling decision are described in details. On-line profit optimization may be done in particular if a process model is available. This is demonstrated with cephalosporin C fed-batch cultivation as an example.
KW - Adaptive model
KW - Cephalosporin
KW - Gibberellic acid
KW - Optimal scheduling
KW - Penicillin
KW - Profit function
UR - http://www.scopus.com/inward/record.url?scp=0031560767&partnerID=8YFLogxK
U2 - 10.1016/S0168-1656(97)01699-4
DO - 10.1016/S0168-1656(97)01699-4
M3 - Article
AN - SCOPUS:0031560767
VL - 54
SP - 175
EP - 193
JO - Journal of biotechnology
JF - Journal of biotechnology
SN - 0168-1656
IS - 3
ER -