Details
| Translated title of the contribution | Herstellung biohybrider Protein/PEO Zellkulturträgerstrukturen durch Elektrospinning |
|---|---|
| Original language | Multiple languages |
| Pages (from-to) | 65-72 |
| Number of pages | 8 |
| Journal | Materialwissenschaft und Werkstofftechnik |
| Volume | 40 |
| Issue number | 1-2 |
| Publication status | Published - Jan 2009 |
Abstract
Electrospun polymeric micro- and nanofibers offer the opportunity to reproduce the filamentous structure of the extracellular matrix in native tissues. The ability to electrospin extracellular matrix proteins offers the additional benefit of being able to create a chemical and structural microenvironment for cells in order to influence their behavior during scaffold seeding and tissue formation. This offers significant advantages over unspecific protein adsorption or functionalisation with adhesion promoting peptide sequences. However, producing electrospun fibers from pure protein solutions remains difficult and costly. A more accessible approach is to introduce proteins into electrospun fibers by blending synthetic polymer solutions with selected extracellular matrix proteins. The correct choice of polymer also makes the usage of toxic and denaturing solvents unnecessary. In this study we have investigated the production process for and the suitability of protein/PEO fibers, specifically collagen I/PEO, as cell culture substrates.
Keywords
- Blectrospinning, Collagen, PEO, Scaffold design, Tissue engineering
ASJC Scopus subject areas
- Materials Science(all)
- General Materials Science
- Physics and Astronomy(all)
- Condensed Matter Physics
- Engineering(all)
- Mechanics of Materials
- Engineering(all)
- Mechanical Engineering
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In: Materialwissenschaft und Werkstofftechnik, Vol. 40, No. 1-2, 01.2009, p. 65-72.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Production of biohybrid protein/PEO scaffolds by electrospinning
AU - Szentivanyi, A.
AU - Assmann, U.
AU - Schuster, R.
AU - Glasmacher, B.
PY - 2009/1
Y1 - 2009/1
N2 - Electrospun polymeric micro- and nanofibers offer the opportunity to reproduce the filamentous structure of the extracellular matrix in native tissues. The ability to electrospin extracellular matrix proteins offers the additional benefit of being able to create a chemical and structural microenvironment for cells in order to influence their behavior during scaffold seeding and tissue formation. This offers significant advantages over unspecific protein adsorption or functionalisation with adhesion promoting peptide sequences. However, producing electrospun fibers from pure protein solutions remains difficult and costly. A more accessible approach is to introduce proteins into electrospun fibers by blending synthetic polymer solutions with selected extracellular matrix proteins. The correct choice of polymer also makes the usage of toxic and denaturing solvents unnecessary. In this study we have investigated the production process for and the suitability of protein/PEO fibers, specifically collagen I/PEO, as cell culture substrates.
AB - Electrospun polymeric micro- and nanofibers offer the opportunity to reproduce the filamentous structure of the extracellular matrix in native tissues. The ability to electrospin extracellular matrix proteins offers the additional benefit of being able to create a chemical and structural microenvironment for cells in order to influence their behavior during scaffold seeding and tissue formation. This offers significant advantages over unspecific protein adsorption or functionalisation with adhesion promoting peptide sequences. However, producing electrospun fibers from pure protein solutions remains difficult and costly. A more accessible approach is to introduce proteins into electrospun fibers by blending synthetic polymer solutions with selected extracellular matrix proteins. The correct choice of polymer also makes the usage of toxic and denaturing solvents unnecessary. In this study we have investigated the production process for and the suitability of protein/PEO fibers, specifically collagen I/PEO, as cell culture substrates.
KW - Blectrospinning
KW - Collagen
KW - PEO
KW - Scaffold design
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=62549124097&partnerID=8YFLogxK
U2 - 10.1002/mawe.200800376
DO - 10.1002/mawe.200800376
M3 - Article
AN - SCOPUS:62549124097
VL - 40
SP - 65
EP - 72
JO - Materialwissenschaft und Werkstofftechnik
JF - Materialwissenschaft und Werkstofftechnik
SN - 0933-5137
IS - 1-2
ER -