Details
| Original language | English |
|---|---|
| Pages (from-to) | 564-584 |
| Number of pages | 21 |
| Journal | NANO TODAY |
| Volume | 6 |
| Issue number | 6 |
| Publication status | Published - Dec 2011 |
| Externally published | Yes |
Abstract
In this contribution, we review the recent literature on an alternative crystallization pathway involving stable clusters prior to nucleation and show that the prenucleation cluster pathway is a truly non-classical concept of nucleation. Prenucleation clusters are solutes with "molecular" character in aqueous solution. It becomes evident that the stable clusters may have been concealed by the so-called ion pair concept and activity effects. We show that non-classical nucleation via stable prenucleation clusters is a highly valuable concept for a novel understanding of phenomena observed in bio- and biomimetic mineralization, which however may hardly be rationalized by means of classical nucleation theory. The importance to combine experimental and theoretical studies is emphasized.
Keywords
- Amorphous precursors, Biomimetic mineralization, Biomineralization, Crystallization, Nucleation, Prenucleation clusters
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Engineering(all)
- Biomedical Engineering
- Materials Science(all)
- General Materials Science
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
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In: NANO TODAY, Vol. 6, No. 6, 12.2011, p. 564-584.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Prenucleation clusters and non-classical nucleation
AU - Gebauer, Denis
AU - Cölfen, Helmut
PY - 2011/12
Y1 - 2011/12
N2 - In this contribution, we review the recent literature on an alternative crystallization pathway involving stable clusters prior to nucleation and show that the prenucleation cluster pathway is a truly non-classical concept of nucleation. Prenucleation clusters are solutes with "molecular" character in aqueous solution. It becomes evident that the stable clusters may have been concealed by the so-called ion pair concept and activity effects. We show that non-classical nucleation via stable prenucleation clusters is a highly valuable concept for a novel understanding of phenomena observed in bio- and biomimetic mineralization, which however may hardly be rationalized by means of classical nucleation theory. The importance to combine experimental and theoretical studies is emphasized.
AB - In this contribution, we review the recent literature on an alternative crystallization pathway involving stable clusters prior to nucleation and show that the prenucleation cluster pathway is a truly non-classical concept of nucleation. Prenucleation clusters are solutes with "molecular" character in aqueous solution. It becomes evident that the stable clusters may have been concealed by the so-called ion pair concept and activity effects. We show that non-classical nucleation via stable prenucleation clusters is a highly valuable concept for a novel understanding of phenomena observed in bio- and biomimetic mineralization, which however may hardly be rationalized by means of classical nucleation theory. The importance to combine experimental and theoretical studies is emphasized.
KW - Amorphous precursors
KW - Biomimetic mineralization
KW - Biomineralization
KW - Crystallization
KW - Nucleation
KW - Prenucleation clusters
UR - http://www.scopus.com/inward/record.url?scp=82955163290&partnerID=8YFLogxK
U2 - 10.1016/j.nantod.2011.10.005
DO - 10.1016/j.nantod.2011.10.005
M3 - Review article
AN - SCOPUS:82955163290
VL - 6
SP - 564
EP - 584
JO - NANO TODAY
JF - NANO TODAY
SN - 1748-0132
IS - 6
ER -