Details
| Original language | English |
|---|---|
| Pages (from-to) | 1813-1817 |
| Number of pages | 5 |
| Journal | ChemBioChem |
| Volume | 13 |
| Issue number | 12 |
| Publication status | Published - 17 Jul 2012 |
Abstract
The antibiotic elansolid C1 (8) was isolated from Chitinophaga sancti strain FxGBF13 after fermentation in the presence of anthranilic acid. Remarkably, 8 was also obtained by addition of anthranilic acid to a crude fermentation extract containing the macrolide elansolid A2 (1*). This Michael-type conjugate addition allowed us to generate 21 new derivatives of elansolid C1 (9-29) by using various nucleophiles. Biological activities of all derivatives were evaluated against Staphylococcus aureus, Micrococcus luteus, and the mouse cell line L929.
Keywords
- Anthranilic acid, Antibiotics, Elansolid, Liquid chromatography, Nucleophiles
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Medicine
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Chemistry(all)
- Organic Chemistry
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In: ChemBioChem, Vol. 13, No. 12, 17.07.2012, p. 1813-1817.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Precursor-Directed Syntheses and Biological Evaluation of New Elansolid Derivatives
AU - Steinmetz, Heinrich
AU - Zander, Wiebke
AU - Shushni, Muftah A.M.
AU - Jansen, Rolf
AU - Gerth, Klaus
AU - Dehn, Richard
AU - Dräger, Gerald
AU - Kirschning, Andreas
AU - Müller, Rolf
PY - 2012/7/17
Y1 - 2012/7/17
N2 - The antibiotic elansolid C1 (8) was isolated from Chitinophaga sancti strain FxGBF13 after fermentation in the presence of anthranilic acid. Remarkably, 8 was also obtained by addition of anthranilic acid to a crude fermentation extract containing the macrolide elansolid A2 (1*). This Michael-type conjugate addition allowed us to generate 21 new derivatives of elansolid C1 (9-29) by using various nucleophiles. Biological activities of all derivatives were evaluated against Staphylococcus aureus, Micrococcus luteus, and the mouse cell line L929.
AB - The antibiotic elansolid C1 (8) was isolated from Chitinophaga sancti strain FxGBF13 after fermentation in the presence of anthranilic acid. Remarkably, 8 was also obtained by addition of anthranilic acid to a crude fermentation extract containing the macrolide elansolid A2 (1*). This Michael-type conjugate addition allowed us to generate 21 new derivatives of elansolid C1 (9-29) by using various nucleophiles. Biological activities of all derivatives were evaluated against Staphylococcus aureus, Micrococcus luteus, and the mouse cell line L929.
KW - Anthranilic acid
KW - Antibiotics
KW - Elansolid
KW - Liquid chromatography
KW - Nucleophiles
UR - http://www.scopus.com/inward/record.url?scp=84864776550&partnerID=8YFLogxK
U2 - 10.1002/cbic.201200228
DO - 10.1002/cbic.201200228
M3 - Article
C2 - 22807264
AN - SCOPUS:84864776550
VL - 13
SP - 1813
EP - 1817
JO - ChemBioChem
JF - ChemBioChem
SN - 1439-4227
IS - 12
ER -