Details
| Original language | English |
|---|---|
| Article number | 50222 |
| Journal | Journal of applied polymer science |
| Volume | 138 |
| Issue number | 16 |
| Publication status | Published - 16 Jan 2021 |
Abstract
In this study, the inherent antibacterial activity of 11 different polymerized ionic liquids (PILs)-based hydrogels as well as their corresponding monomers was examined in an extensive screening. The methicillin-resistant Staphylococcus aureus Xen 30 (MRSA Xen 30) and Pseudomonas aeruginosa Xen 5 (P. aeruginosa Xen 5) were chosen as test microorganisms. Both are typical representatives of gram-positive and gram-negative bacteria, respectively. Six of the 11 tested monomers were able to eradicate more than 80% of P. aeruginosa Xen 5 cells in suspension. Unfortunately, the anionic, neutral and zwitterionic representatives lost their function after polymerization. However, the cationic gels retained their antibacterial activity with nearly 100% eradication of selected microorganisms - even at the smallest amount tested. Bactericidal activity against gram-positive MRSA Xen 30 was high when the bacteria were treated with the imidazolium-based monomers. Five of the tested compounds showed rather limited bactericidal activity <50% killed bacteria. The weak antibacterial activities could be significantly increased by crosslinking them to three-dimensional networks. As a result, all the hydrogels possessed strong killing efficiencies of at least 68% and were able to maintain this activity even at low hydrogel volume fractions. These findings are very promising for the development of new antibacterial materials for medical applications, for example, stent coatings.
ASJC Scopus subject areas
- Chemistry(all)
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Polymers and Plastics
- Materials Science(all)
- Materials Chemistry
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In: Journal of applied polymer science, Vol. 138, No. 16, 50222, 16.01.2021.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Polymerized ionic liquids-based hydrogels with intrinsic antibacterial activity
T2 - Modern weapons against antibiotic-resistant infections
AU - Claus, Johanna
AU - Jastram, Ann
AU - Piktel, Ewelina
AU - Bucki, Robert
AU - Janmey, Paul A.
AU - Kragl, Udo
N1 - Funding Information: We acknowledge the financial support by the Deutsche Forschungsgemeinschaft and the University of Rostock within the funding programme Open Access Publishing. Funding by the Federal Ministry of Education and Research within RESPONSE “Partnership for Innovation in Implant Technology” (FKZ 03ZZ0910B) and the Deutsche Forschungsgemeinschaft (DFG; grant KR 2491/12‐2) as well as the HERMES research funding of the University of Rostock is gratefully acknowledged. We also thank Katrin Feest for proof reading and Fitzroy Byfield for the technical support.
PY - 2021/1/16
Y1 - 2021/1/16
N2 - In this study, the inherent antibacterial activity of 11 different polymerized ionic liquids (PILs)-based hydrogels as well as their corresponding monomers was examined in an extensive screening. The methicillin-resistant Staphylococcus aureus Xen 30 (MRSA Xen 30) and Pseudomonas aeruginosa Xen 5 (P. aeruginosa Xen 5) were chosen as test microorganisms. Both are typical representatives of gram-positive and gram-negative bacteria, respectively. Six of the 11 tested monomers were able to eradicate more than 80% of P. aeruginosa Xen 5 cells in suspension. Unfortunately, the anionic, neutral and zwitterionic representatives lost their function after polymerization. However, the cationic gels retained their antibacterial activity with nearly 100% eradication of selected microorganisms - even at the smallest amount tested. Bactericidal activity against gram-positive MRSA Xen 30 was high when the bacteria were treated with the imidazolium-based monomers. Five of the tested compounds showed rather limited bactericidal activity <50% killed bacteria. The weak antibacterial activities could be significantly increased by crosslinking them to three-dimensional networks. As a result, all the hydrogels possessed strong killing efficiencies of at least 68% and were able to maintain this activity even at low hydrogel volume fractions. These findings are very promising for the development of new antibacterial materials for medical applications, for example, stent coatings.
AB - In this study, the inherent antibacterial activity of 11 different polymerized ionic liquids (PILs)-based hydrogels as well as their corresponding monomers was examined in an extensive screening. The methicillin-resistant Staphylococcus aureus Xen 30 (MRSA Xen 30) and Pseudomonas aeruginosa Xen 5 (P. aeruginosa Xen 5) were chosen as test microorganisms. Both are typical representatives of gram-positive and gram-negative bacteria, respectively. Six of the 11 tested monomers were able to eradicate more than 80% of P. aeruginosa Xen 5 cells in suspension. Unfortunately, the anionic, neutral and zwitterionic representatives lost their function after polymerization. However, the cationic gels retained their antibacterial activity with nearly 100% eradication of selected microorganisms - even at the smallest amount tested. Bactericidal activity against gram-positive MRSA Xen 30 was high when the bacteria were treated with the imidazolium-based monomers. Five of the tested compounds showed rather limited bactericidal activity <50% killed bacteria. The weak antibacterial activities could be significantly increased by crosslinking them to three-dimensional networks. As a result, all the hydrogels possessed strong killing efficiencies of at least 68% and were able to maintain this activity even at low hydrogel volume fractions. These findings are very promising for the development of new antibacterial materials for medical applications, for example, stent coatings.
UR - http://www.scopus.com/inward/record.url?scp=85094645495&partnerID=8YFLogxK
U2 - 10.1002/app.50222
DO - 10.1002/app.50222
M3 - Article
AN - SCOPUS:85094645495
VL - 138
JO - Journal of applied polymer science
JF - Journal of applied polymer science
SN - 0021-8995
IS - 16
M1 - 50222
ER -