Details
| Original language | English |
|---|---|
| Pages (from-to) | 241-249 |
| Number of pages | 9 |
| Journal | Journal of Chromatography A |
| Volume | 1006 |
| Issue number | 1-2 |
| Publication status | Published - 23 May 2003 |
Abstract
In this work new polymer/carrier composites are described which serve as novel materials in flow-through reactors for polymer-supported organic solution-phase synthesis. Monolithic polymer/carrier columns are prepared by a new precipitation polymerization process inside the void pore volume of megaporous glass carrier materials. Chemical functionalization of the internal polymer phase with chlorosulfonic acid or trimethylamine generates small, interconnected ion-exchange resin beads with a diameter of 1-3μm which can be used for a large variety of organic syntheses. These monolithic rods are incorporated into an appropriate casing and can conveniently be operated in the flow-through mode. Important successful applications are polymer-assisted solution-phase reductions, oxidations and Horner-Emmons olefinations. Additionally, the use of these monolithic columns as catalytic microreactors and their performance in selected reactions are described.
Keywords
- Catalysts, Horner-Emmons olefination, Monolithic polymer/carrier microreactor, Polymer-supported reagents, Suzuki cross-coupling reaction
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Organic Chemistry
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In: Journal of Chromatography A, Vol. 1006, No. 1-2, 23.05.2003, p. 241-249.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Polymer/carrier composites as materials and reactors for organic synthesis
AU - Kunz, Ulrich
AU - Schönfeld, Hagen
AU - Kirschning, Andreas
AU - Solodenko, Wladimir
N1 - Funding information: Financial support by the Fonds der Chemischen Industrie, the Max-Buchner-Stiftung and Chelona is gratefully acknowledged. The presented flow-through microreactors as well as automated synthesis stations for efficient laboratory use of the reactors are available from Chelona, Hermannswerder Haus 15, D-14473 Potsdam, Germany ( www.chelona.com ).
PY - 2003/5/23
Y1 - 2003/5/23
N2 - In this work new polymer/carrier composites are described which serve as novel materials in flow-through reactors for polymer-supported organic solution-phase synthesis. Monolithic polymer/carrier columns are prepared by a new precipitation polymerization process inside the void pore volume of megaporous glass carrier materials. Chemical functionalization of the internal polymer phase with chlorosulfonic acid or trimethylamine generates small, interconnected ion-exchange resin beads with a diameter of 1-3μm which can be used for a large variety of organic syntheses. These monolithic rods are incorporated into an appropriate casing and can conveniently be operated in the flow-through mode. Important successful applications are polymer-assisted solution-phase reductions, oxidations and Horner-Emmons olefinations. Additionally, the use of these monolithic columns as catalytic microreactors and their performance in selected reactions are described.
AB - In this work new polymer/carrier composites are described which serve as novel materials in flow-through reactors for polymer-supported organic solution-phase synthesis. Monolithic polymer/carrier columns are prepared by a new precipitation polymerization process inside the void pore volume of megaporous glass carrier materials. Chemical functionalization of the internal polymer phase with chlorosulfonic acid or trimethylamine generates small, interconnected ion-exchange resin beads with a diameter of 1-3μm which can be used for a large variety of organic syntheses. These monolithic rods are incorporated into an appropriate casing and can conveniently be operated in the flow-through mode. Important successful applications are polymer-assisted solution-phase reductions, oxidations and Horner-Emmons olefinations. Additionally, the use of these monolithic columns as catalytic microreactors and their performance in selected reactions are described.
KW - Catalysts
KW - Horner-Emmons olefination
KW - Monolithic polymer/carrier microreactor
KW - Polymer-supported reagents
KW - Suzuki cross-coupling reaction
UR - http://www.scopus.com/inward/record.url?scp=0041846562&partnerID=8YFLogxK
U2 - 10.1016/S0021-9673(03)00556-9
DO - 10.1016/S0021-9673(03)00556-9
M3 - Article
C2 - 12938889
AN - SCOPUS:0041846562
VL - 1006
SP - 241
EP - 249
JO - Journal of Chromatography A
JF - Journal of Chromatography A
SN - 0021-9673
IS - 1-2
ER -