Details
| Original language | English |
|---|---|
| Title of host publication | From Biosynthesis to Total Synthesis |
| Subtitle of host publication | Strategies and Tactics for Natural Products |
| Publisher | Wiley-Blackwell |
| Pages | 19-129 |
| Number of pages | 111 |
| ISBN (electronic) | 9781118754085 |
| ISBN (print) | 9781118751732 |
| Publication status | Published - 22 Apr 2016 |
Abstract
Polyketides are a fascinating class of natural products with highly diverse, often complex structures combined with a likewise impressive breath of strong and selective biological activities. This chapter discusses the logic of biosynthetic polyketide assembly. It focuses on the introduction of the basic mechanisms and concepts of polyketide core structure assembly using a number of well-studied representative examples, thus allowing to compare the biosynthetic versus chemical synthetic strategies to assemble such beautiful small molecules. Despite the structural diversity of polyketide natural products, there are only few different catalytic domains facilitating a small number of basic reactions common to all types of PKSs that are crucial for product biosynthesis. The structural and functional space covered by bioactive small molecules is further expanded by post-PKS functionalization reactions catalyzed by so-called tailoring enzymes. This includes reorganization of the entire PKS core but also subtle changes by group transfer reactions or oxidative transformations.
Keywords
- Biosynthetic pathway, Chemical synthesis, Group transfer reactions, Oxidative transformations, Polyketides
ASJC Scopus subject areas
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From Biosynthesis to Total Synthesis: Strategies and Tactics for Natural Products. Wiley-Blackwell, 2016. p. 19-129.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - Polyketides
AU - Schaefers, Françoise
AU - Gulder, Tobias A.M.
AU - Bressy, Cyril
AU - Smietana, Michael
AU - Benedetti, Erica
AU - Arseniyadis, Stellios
AU - Kalesse, Markus
AU - Cordes, Martin
PY - 2016/4/22
Y1 - 2016/4/22
N2 - Polyketides are a fascinating class of natural products with highly diverse, often complex structures combined with a likewise impressive breath of strong and selective biological activities. This chapter discusses the logic of biosynthetic polyketide assembly. It focuses on the introduction of the basic mechanisms and concepts of polyketide core structure assembly using a number of well-studied representative examples, thus allowing to compare the biosynthetic versus chemical synthetic strategies to assemble such beautiful small molecules. Despite the structural diversity of polyketide natural products, there are only few different catalytic domains facilitating a small number of basic reactions common to all types of PKSs that are crucial for product biosynthesis. The structural and functional space covered by bioactive small molecules is further expanded by post-PKS functionalization reactions catalyzed by so-called tailoring enzymes. This includes reorganization of the entire PKS core but also subtle changes by group transfer reactions or oxidative transformations.
AB - Polyketides are a fascinating class of natural products with highly diverse, often complex structures combined with a likewise impressive breath of strong and selective biological activities. This chapter discusses the logic of biosynthetic polyketide assembly. It focuses on the introduction of the basic mechanisms and concepts of polyketide core structure assembly using a number of well-studied representative examples, thus allowing to compare the biosynthetic versus chemical synthetic strategies to assemble such beautiful small molecules. Despite the structural diversity of polyketide natural products, there are only few different catalytic domains facilitating a small number of basic reactions common to all types of PKSs that are crucial for product biosynthesis. The structural and functional space covered by bioactive small molecules is further expanded by post-PKS functionalization reactions catalyzed by so-called tailoring enzymes. This includes reorganization of the entire PKS core but also subtle changes by group transfer reactions or oxidative transformations.
KW - Biosynthetic pathway
KW - Chemical synthesis
KW - Group transfer reactions
KW - Oxidative transformations
KW - Polyketides
UR - http://www.scopus.com/inward/record.url?scp=85026566193&partnerID=8YFLogxK
U2 - 10.1002/9781118754085.ch2
DO - 10.1002/9781118754085.ch2
M3 - Contribution to book/anthology
AN - SCOPUS:85026566193
SN - 9781118751732
SP - 19
EP - 129
BT - From Biosynthesis to Total Synthesis
PB - Wiley-Blackwell
ER -