Details
| Original language | English |
|---|---|
| Pages (from-to) | 2798-2813 |
| Number of pages | 16 |
| Journal | Journal of separation science |
| Volume | 44 |
| Issue number | 14 |
| Early online date | 4 May 2021 |
| Publication status | Published - Jul 2021 |
Abstract
In a previous work, we explored zone broadening and the achievable plate numbers in linear drift tube ion mobility-mass spectrometry through developing a plate-height model [1]. On the basis of these findings, the present theoretical study extends the model by exploring peak-to-peak resolution and peak capacity in ion mobility separations. The first part provides a critical overview of chromatography-influenced resolution equations, including refinement of existing formulae. Furthermore, we present exact resolution equations for drift tube ion mobility spectrometry based on first principles. Upon implementing simple modifications, these exact formulae could be readily extended to traveling wave ion mobility separations and to cases when ion mobility spectrometry is coupled to mass spectrometry. The second part focuses on peak capacity. The well-known assumptions of constant plate number and constant peak width form the basis of existing approximate solutions. To overcome their limitations, an exact peak capacity equation is derived for drift tube ion mobility spectrometry. This exact solution is rooted in a suitable physical model of peak broadening, accounting for the finite injection pulse and subsequent diffusional spreading. By borrowing concepts from the theoretical toolbox of chromatography, we believe that the present study will help in integrating ion mobility spectrometry into the unified language of separation science.
Keywords
- drift tube, ion mobility spectrometry, peak capacity, peak resolution, traveling wave
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Chemical Engineering(all)
- Filtration and Separation
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In: Journal of separation science, Vol. 44, No. 14, 07.2021, p. 2798-2813.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Plate-height model of ion mobility-mass spectrometry
T2 - Part 2—Peak-to-peak resolution and peak capacity
AU - Grabarics, Márkó
AU - Lettow, Maike
AU - Kirk, Ansgar T.
AU - von Helden, Gert
AU - Causon, Tim J.
AU - Pagel, Kevin
N1 - Funding Information: The authors gratefully acknowledge financial support from the Freie Universität Berlin and the Max Planck Society. This research was funded by the German Research Foundation within the framework of the research unit FOR 2177 (“Integrated Chemical Micro Laboratories”) project number PA 1766/3‐1.
PY - 2021/7
Y1 - 2021/7
N2 - In a previous work, we explored zone broadening and the achievable plate numbers in linear drift tube ion mobility-mass spectrometry through developing a plate-height model [1]. On the basis of these findings, the present theoretical study extends the model by exploring peak-to-peak resolution and peak capacity in ion mobility separations. The first part provides a critical overview of chromatography-influenced resolution equations, including refinement of existing formulae. Furthermore, we present exact resolution equations for drift tube ion mobility spectrometry based on first principles. Upon implementing simple modifications, these exact formulae could be readily extended to traveling wave ion mobility separations and to cases when ion mobility spectrometry is coupled to mass spectrometry. The second part focuses on peak capacity. The well-known assumptions of constant plate number and constant peak width form the basis of existing approximate solutions. To overcome their limitations, an exact peak capacity equation is derived for drift tube ion mobility spectrometry. This exact solution is rooted in a suitable physical model of peak broadening, accounting for the finite injection pulse and subsequent diffusional spreading. By borrowing concepts from the theoretical toolbox of chromatography, we believe that the present study will help in integrating ion mobility spectrometry into the unified language of separation science.
AB - In a previous work, we explored zone broadening and the achievable plate numbers in linear drift tube ion mobility-mass spectrometry through developing a plate-height model [1]. On the basis of these findings, the present theoretical study extends the model by exploring peak-to-peak resolution and peak capacity in ion mobility separations. The first part provides a critical overview of chromatography-influenced resolution equations, including refinement of existing formulae. Furthermore, we present exact resolution equations for drift tube ion mobility spectrometry based on first principles. Upon implementing simple modifications, these exact formulae could be readily extended to traveling wave ion mobility separations and to cases when ion mobility spectrometry is coupled to mass spectrometry. The second part focuses on peak capacity. The well-known assumptions of constant plate number and constant peak width form the basis of existing approximate solutions. To overcome their limitations, an exact peak capacity equation is derived for drift tube ion mobility spectrometry. This exact solution is rooted in a suitable physical model of peak broadening, accounting for the finite injection pulse and subsequent diffusional spreading. By borrowing concepts from the theoretical toolbox of chromatography, we believe that the present study will help in integrating ion mobility spectrometry into the unified language of separation science.
KW - drift tube
KW - ion mobility spectrometry
KW - peak capacity
KW - peak resolution
KW - traveling wave
UR - http://www.scopus.com/inward/record.url?scp=85107040365&partnerID=8YFLogxK
U2 - 10.1002/jssc.202100201
DO - 10.1002/jssc.202100201
M3 - Article
C2 - 33945207
AN - SCOPUS:85107040365
VL - 44
SP - 2798
EP - 2813
JO - Journal of separation science
JF - Journal of separation science
SN - 1615-9306
IS - 14
ER -