Details
| Original language | English |
|---|---|
| Pages (from-to) | 33-36 |
| Number of pages | 4 |
| Journal | Current Directions in Biomedical Engineering |
| Volume | 9 |
| Issue number | 1 |
| Publication status | Published - 1 Sept 2023 |
Abstract
Implant-Associated infections are still a major issue in implant surgery. Biofilms tend to form on implant surfaces, like titanium, and can hardly be reached by the immune system. Additionally, systemic treatments with antibiotics often fail and cause severe side effects for the patient. Direct delivery of the antibiotic from the implant surface to the surrounding tissue is one approach to solve this problem. To realize this, the application of pH-sensitive coatings on implant surfaces, which release their cargo only if an infection arises, is a promising option. This can be triggered by the decrease of the pH value occurring in infected tissue. For such pH-sensitive systems with integrated drug loading capacity layer-by-layer coatings with weak polyelectrolytes can be used. Here, we present a coating applied on titanium substrates by dip-coating. As negatively charged polyelectrolyte polyacrylic acid, as positively charged poly(allylamine hydrochloride) is used. As an effective drug, the antibiotic ciprofloxacin is incorporated into the coating and the release profiles are recorded.
Keywords
- ciprofloxacin, implant-Associated infection, layer-by-layer coating, pH-Triggered drug release
ASJC Scopus subject areas
- Engineering(all)
- Biomedical Engineering
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In: Current Directions in Biomedical Engineering, Vol. 9, No. 1, 01.09.2023, p. 33-36.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - PH-Triggered drug release of ciprofloxacin from layer-by-layer coatings on titanium
AU - Ehlert, Nina
AU - Rieks, Desiree
AU - Kampmann, Andreas
AU - Gellrich, Nils Claudius
N1 - Research funding: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – SFB/TRR-298-SIIRI – Project-ID 426335750. Conflict of interest: Authors state no conflict of interest. Informed consent: Informed consent has been obtained from all individuals included in this study.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Implant-Associated infections are still a major issue in implant surgery. Biofilms tend to form on implant surfaces, like titanium, and can hardly be reached by the immune system. Additionally, systemic treatments with antibiotics often fail and cause severe side effects for the patient. Direct delivery of the antibiotic from the implant surface to the surrounding tissue is one approach to solve this problem. To realize this, the application of pH-sensitive coatings on implant surfaces, which release their cargo only if an infection arises, is a promising option. This can be triggered by the decrease of the pH value occurring in infected tissue. For such pH-sensitive systems with integrated drug loading capacity layer-by-layer coatings with weak polyelectrolytes can be used. Here, we present a coating applied on titanium substrates by dip-coating. As negatively charged polyelectrolyte polyacrylic acid, as positively charged poly(allylamine hydrochloride) is used. As an effective drug, the antibiotic ciprofloxacin is incorporated into the coating and the release profiles are recorded.
AB - Implant-Associated infections are still a major issue in implant surgery. Biofilms tend to form on implant surfaces, like titanium, and can hardly be reached by the immune system. Additionally, systemic treatments with antibiotics often fail and cause severe side effects for the patient. Direct delivery of the antibiotic from the implant surface to the surrounding tissue is one approach to solve this problem. To realize this, the application of pH-sensitive coatings on implant surfaces, which release their cargo only if an infection arises, is a promising option. This can be triggered by the decrease of the pH value occurring in infected tissue. For such pH-sensitive systems with integrated drug loading capacity layer-by-layer coatings with weak polyelectrolytes can be used. Here, we present a coating applied on titanium substrates by dip-coating. As negatively charged polyelectrolyte polyacrylic acid, as positively charged poly(allylamine hydrochloride) is used. As an effective drug, the antibiotic ciprofloxacin is incorporated into the coating and the release profiles are recorded.
KW - ciprofloxacin
KW - implant-Associated infection
KW - layer-by-layer coating
KW - pH-Triggered drug release
UR - http://www.scopus.com/inward/record.url?scp=85173265573&partnerID=8YFLogxK
U2 - 10.1515/cdbme-2023-1009
DO - 10.1515/cdbme-2023-1009
M3 - Article
AN - SCOPUS:85173265573
VL - 9
SP - 33
EP - 36
JO - Current Directions in Biomedical Engineering
JF - Current Directions in Biomedical Engineering
IS - 1
ER -