Details
| Original language | English |
|---|---|
| Pages (from-to) | 59-72 |
| Number of pages | 14 |
| Journal | BioNanoMaterials |
| Volume | 17 |
| Issue number | 1-2 |
| Publication status | Published - 1 May 2016 |
Abstract
A pH-sensitive stimulus-response system for controlled drug release was prepared by modifying nanoporous silica nanoparticles (NPSNPs) with poly(4-vinylpyridine) using a bismaleimide as linker. At physiological pH values, the polymer serves as gate keeper blocking the pore openings to prevent the release of cargo molecules. At acidic pH values as they can occur during a bacterial infection, the polymer strains become protonated and straighten up due to electrostatic repulsion. The pores are opened and the cargo is released. The drug chlorhexidine was loaded into the pores because of its excellent antibacterial properties and low tendency to form resistances. The release was performed in PBS and diluted hydrochloric acid, respectively. The results showed a considerably higher release in acidic media compared to neutral solvents. Reversibility of this pH-dependent release was established. In vitro tests proved good cytocompatibility of the prepared nanoparticles. Antibacterial activity tests with Streptococcus mutans and Staphylococcus aureus revealed promising perspectives of the release system for biofilm prevention. The developed polymer-modified silica nanoparticles can serve as an efficient controlled drug release system for long-term delivery in biomedical applications, such as in treatment of biofilm-associated infections, and could, for example, be used as medical implant coating or as components in dental composite materials.
Keywords
- chlorhexidine, controlled drug delivery, dental application, pH-responsive release, silica nanoparticles, stimulus-responsive
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Engineering(all)
- Biomedical Engineering
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In: BioNanoMaterials, Vol. 17, No. 1-2, 01.05.2016, p. 59-72.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - PH-responsive release of chlorhexidine from modified nanoporous silica nanoparticles for dental applications
AU - Fullriede, Hendrik
AU - Abendroth, Philipp
AU - Ehlert, Nina
AU - Doll, Katharina
AU - Schäske, Jörn
AU - Winkel, Andreas
AU - Stumpp, Sascha Nico
AU - Stiesch, Meike
AU - Behrens, Peter
N1 - Funding Information: This work was funded by the Deutsche Forschungsgemeinschaft as part of the Collaborative Research Center SFB 599 (project D12) and by the research initiative "Biofabrication for NIFE". The authors thank Natalja Wendt and Jann Lippke (Gottfried Wilhelm Leibniz Universität Hannover) for carrying out the sorption measurements, Katharina Nolte and Sergej Springer (Gottfried Wilhelm Leibniz Universität Hannover) for thermogravimetric analysis and Dr. Britta Hering (Gottfried Wilhelm Leibniz Universität Hannover) for performing the SEM imaging. Gratitude also goes to Prof. Dr. Henning Menzel (Technische Universität Braunschweig) for scientific support in the field of polymers.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - A pH-sensitive stimulus-response system for controlled drug release was prepared by modifying nanoporous silica nanoparticles (NPSNPs) with poly(4-vinylpyridine) using a bismaleimide as linker. At physiological pH values, the polymer serves as gate keeper blocking the pore openings to prevent the release of cargo molecules. At acidic pH values as they can occur during a bacterial infection, the polymer strains become protonated and straighten up due to electrostatic repulsion. The pores are opened and the cargo is released. The drug chlorhexidine was loaded into the pores because of its excellent antibacterial properties and low tendency to form resistances. The release was performed in PBS and diluted hydrochloric acid, respectively. The results showed a considerably higher release in acidic media compared to neutral solvents. Reversibility of this pH-dependent release was established. In vitro tests proved good cytocompatibility of the prepared nanoparticles. Antibacterial activity tests with Streptococcus mutans and Staphylococcus aureus revealed promising perspectives of the release system for biofilm prevention. The developed polymer-modified silica nanoparticles can serve as an efficient controlled drug release system for long-term delivery in biomedical applications, such as in treatment of biofilm-associated infections, and could, for example, be used as medical implant coating or as components in dental composite materials.
AB - A pH-sensitive stimulus-response system for controlled drug release was prepared by modifying nanoporous silica nanoparticles (NPSNPs) with poly(4-vinylpyridine) using a bismaleimide as linker. At physiological pH values, the polymer serves as gate keeper blocking the pore openings to prevent the release of cargo molecules. At acidic pH values as they can occur during a bacterial infection, the polymer strains become protonated and straighten up due to electrostatic repulsion. The pores are opened and the cargo is released. The drug chlorhexidine was loaded into the pores because of its excellent antibacterial properties and low tendency to form resistances. The release was performed in PBS and diluted hydrochloric acid, respectively. The results showed a considerably higher release in acidic media compared to neutral solvents. Reversibility of this pH-dependent release was established. In vitro tests proved good cytocompatibility of the prepared nanoparticles. Antibacterial activity tests with Streptococcus mutans and Staphylococcus aureus revealed promising perspectives of the release system for biofilm prevention. The developed polymer-modified silica nanoparticles can serve as an efficient controlled drug release system for long-term delivery in biomedical applications, such as in treatment of biofilm-associated infections, and could, for example, be used as medical implant coating or as components in dental composite materials.
KW - chlorhexidine
KW - controlled drug delivery
KW - dental application
KW - pH-responsive release
KW - silica nanoparticles
KW - stimulus-responsive
UR - http://www.scopus.com/inward/record.url?scp=84986564085&partnerID=8YFLogxK
U2 - 10.1515/bnm-2016-0003
DO - 10.1515/bnm-2016-0003
M3 - Article
AN - SCOPUS:84986564085
VL - 17
SP - 59
EP - 72
JO - BioNanoMaterials
JF - BioNanoMaterials
SN - 2193-0651
IS - 1-2
ER -